Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.

Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...

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Autores principales:	Susana Sánchez-Tena, Fernando J Reyes-Zurita, Santiago Díaz-Moralli, Maria Pilar Vinardell, Michelle Reed, Francisco García-García, Joaquín Dopazo, José A Lupiáñez, Ulrich Günther, Marta Cascante
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ef617bb83ef4537872114fe3232c67b
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spelling	oai:doaj.org-article:5ef617bb83ef4537872114fe3232c67b2021-11-18T07:53:06ZMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.1932-620310.1371/journal.pone.0059392https://doaj.org/article/5ef617bb83ef4537872114fe3232c67b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527181/?tool=EBIhttps://doaj.org/toc/1932-6203Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P<0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in Apc(Min/+) mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the Apc(Min/+) mice model, suggesting its chemopreventive potential against colorectal cancer.Susana Sánchez-TenaFernando J Reyes-ZuritaSantiago Díaz-MoralliMaria Pilar VinardellMichelle ReedFrancisco García-GarcíaJoaquín DopazoJosé A LupiáñezUlrich GüntherMarta CascantePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59392 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susana Sánchez-Tena Fernando J Reyes-Zurita Santiago Díaz-Moralli Maria Pilar Vinardell Michelle Reed Francisco García-García Joaquín Dopazo José A Lupiáñez Ulrich Günther Marta Cascante Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.
description	Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P<0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in Apc(Min/+) mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the Apc(Min/+) mice model, suggesting its chemopreventive potential against colorectal cancer.
format	article
author	Susana Sánchez-Tena Fernando J Reyes-Zurita Santiago Díaz-Moralli Maria Pilar Vinardell Michelle Reed Francisco García-García Joaquín Dopazo José A Lupiáñez Ulrich Günther Marta Cascante
author_facet	Susana Sánchez-Tena Fernando J Reyes-Zurita Santiago Díaz-Moralli Maria Pilar Vinardell Michelle Reed Francisco García-García Joaquín Dopazo José A Lupiáñez Ulrich Günther Marta Cascante
author_sort	Susana Sánchez-Tena
title	Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.
title_short	Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.
title_full	Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.
title_fullStr	Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.
title_full_unstemmed	Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.
title_sort	maslinic acid-enriched diet decreases intestinal tumorigenesis in apc(min/+) mice through transcriptomic and metabolomic reprogramming.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5ef617bb83ef4537872114fe3232c67b
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Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming.

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