Inhibition of human dyskerin as a new approach to target ribosome biogenesis.

Inhibition of human dyskerin as a new approach to target ribosome biogenesis.

The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting these cellular processes has been explored for the development of drugs to selectively or preferentially kill cancer cells. Presently, intense research is conducted involv...

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Autores principales: Laura Rocchi, Arménio J M Barbosa, Carmine Onofrillo, Alberto Del Rio, Lorenzo Montanaro
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/5efc0721b12048fd853604959789ddf1
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