VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.

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Autores principales:	Steve Cornick, Manish Kumar, France Moreau, Herbert Gaisano, Kris Chadee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5efc315bfa514f489f437ae8d29afae4
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spelling	oai:doaj.org-article:5efc315bfa514f489f437ae8d29afae42021-12-02T17:31:53ZVAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis10.1038/s41467-019-11811-82041-1723https://doaj.org/article/5efc315bfa514f489f437ae8d29afae42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11811-8https://doaj.org/toc/2041-1723VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.Steve CornickManish KumarFrance MoreauHerbert GaisanoKris ChadeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steve Cornick Manish Kumar France Moreau Herbert Gaisano Kris Chadee VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
description	VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.
format	article
author	Steve Cornick Manish Kumar France Moreau Herbert Gaisano Kris Chadee
author_facet	Steve Cornick Manish Kumar France Moreau Herbert Gaisano Kris Chadee
author_sort	Steve Cornick
title	VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_short	VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_full	VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_fullStr	VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_full_unstemmed	VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_sort	vamp8-mediated muc2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5efc315bfa514f489f437ae8d29afae4
work_keys_str_mv	AT stevecornick vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis AT manishkumar vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis AT francemoreau vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis AT herbertgaisano vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis AT krischadee vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis
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VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

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