Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice

Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and rodent studies suggest that hypersensitivity to reward may contribute towards such vulnerability when adolescents are exposed to casual drug use. Methamphetamine is a popular illicit substance used by...

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Autores principales:	Ellen R. Cullity, Alexandre A. Guerin, Christina J. Perry, Jee Hyun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adolescence methamphetamine conditioned place preference conditioned place aversion sex differences Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5f034ed8a31c4d989e4552ad05cf2779
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spelling	oai:doaj.org-article:5f034ed8a31c4d989e4552ad05cf27792021-12-01T19:02:51ZExamining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice1663-981210.3389/fphar.2021.770614https://doaj.org/article/5f034ed8a31c4d989e4552ad05cf27792021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.770614/fullhttps://doaj.org/toc/1663-9812Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and rodent studies suggest that hypersensitivity to reward may contribute towards such vulnerability when adolescents are exposed to casual drug use. Methamphetamine is a popular illicit substance used by male and female youths. However, age- and sex-specific research in methamphetamine is scarce. The present study therefore aimed to examine potential sex differences in methamphetamine-conditioned place preference in adolescent and adult mice. Mice (n = 16–24/group) were conditioned to methamphetamine (0.1 mg/kg). We observed that regardless of age, females were more hyperactive compared to males. Individually normalized score against baseline preference indicated that on average, adolescents formed stronger preference compared to adults in both sexes. This suggests that adolescents are more sensitive to the rewarding effects of methamphetamine compared to adults. Surprisingly, individual data showed that some mice formed a conditioned place aversion instead of preference, with females less likely to form an aversion compared to males. These results suggest that adolescents may be hypersensitive to methamphetamine’s rewarding effects. In addition, female resistance to the aversive effects of methamphetamine may relate to the sex-specific findings in humans, including quicker transition to regular methamphetamine use observed in females compared to males.Ellen R. CullityEllen R. CullityAlexandre A. GuerinAlexandre A. GuerinChristina J. PerryChristina J. PerryJee Hyun KimJee Hyun KimJee Hyun KimFrontiers Media S.A.articleadolescencemethamphetamineconditioned place preferenceconditioned place aversionsex differencesTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adolescence methamphetamine conditioned place preference conditioned place aversion sex differences Therapeutics. Pharmacology RM1-950
spellingShingle	adolescence methamphetamine conditioned place preference conditioned place aversion sex differences Therapeutics. Pharmacology RM1-950 Ellen R. Cullity Ellen R. Cullity Alexandre A. Guerin Alexandre A. Guerin Christina J. Perry Christina J. Perry Jee Hyun Kim Jee Hyun Kim Jee Hyun Kim Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice
description	Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and rodent studies suggest that hypersensitivity to reward may contribute towards such vulnerability when adolescents are exposed to casual drug use. Methamphetamine is a popular illicit substance used by male and female youths. However, age- and sex-specific research in methamphetamine is scarce. The present study therefore aimed to examine potential sex differences in methamphetamine-conditioned place preference in adolescent and adult mice. Mice (n = 16–24/group) were conditioned to methamphetamine (0.1 mg/kg). We observed that regardless of age, females were more hyperactive compared to males. Individually normalized score against baseline preference indicated that on average, adolescents formed stronger preference compared to adults in both sexes. This suggests that adolescents are more sensitive to the rewarding effects of methamphetamine compared to adults. Surprisingly, individual data showed that some mice formed a conditioned place aversion instead of preference, with females less likely to form an aversion compared to males. These results suggest that adolescents may be hypersensitive to methamphetamine’s rewarding effects. In addition, female resistance to the aversive effects of methamphetamine may relate to the sex-specific findings in humans, including quicker transition to regular methamphetamine use observed in females compared to males.
format	article
author	Ellen R. Cullity Ellen R. Cullity Alexandre A. Guerin Alexandre A. Guerin Christina J. Perry Christina J. Perry Jee Hyun Kim Jee Hyun Kim Jee Hyun Kim
author_facet	Ellen R. Cullity Ellen R. Cullity Alexandre A. Guerin Alexandre A. Guerin Christina J. Perry Christina J. Perry Jee Hyun Kim Jee Hyun Kim Jee Hyun Kim
author_sort	Ellen R. Cullity
title	Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice
title_short	Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice
title_full	Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice
title_fullStr	Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice
title_full_unstemmed	Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice
title_sort	examining sex differences in conditioned place preference or aversion to methamphetamine in adolescent and adult mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5f034ed8a31c4d989e4552ad05cf2779
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Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice

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