OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.

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Autores principales:	Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger, Helmut Klocker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f0501c636064d6cb8123ea16319c072
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spelling	oai:doaj.org-article:5f0501c636064d6cb8123ea16319c0722021-12-02T15:39:26ZOXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation10.1038/s41467-020-15237-52041-1723https://doaj.org/article/5f0501c636064d6cb8123ea16319c0722020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15237-5https://doaj.org/toc/2041-1723The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.Bernd SchöpfHansi WeissensteinerGeorg SchäferFederica FazziniPornpimol CharoentongAndreas NaschbergerBernhard RuppLiane FendtValesca BukurIrina GiesePatrick SornAna Carolina Sant’Anna-SilvaJavier Iglesias-GonzalezUgur SahinFlorian KronenbergErich GnaigerHelmut KlockerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernd Schöpf Hansi Weissensteiner Georg Schäfer Federica Fazzini Pornpimol Charoentong Andreas Naschberger Bernhard Rupp Liane Fendt Valesca Bukur Irina Giese Patrick Sorn Ana Carolina Sant’Anna-Silva Javier Iglesias-Gonzalez Ugur Sahin Florian Kronenberg Erich Gnaiger Helmut Klocker OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
description	The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.
format	article
author	Bernd Schöpf Hansi Weissensteiner Georg Schäfer Federica Fazzini Pornpimol Charoentong Andreas Naschberger Bernhard Rupp Liane Fendt Valesca Bukur Irina Giese Patrick Sorn Ana Carolina Sant’Anna-Silva Javier Iglesias-Gonzalez Ugur Sahin Florian Kronenberg Erich Gnaiger Helmut Klocker
author_facet	Bernd Schöpf Hansi Weissensteiner Georg Schäfer Federica Fazzini Pornpimol Charoentong Andreas Naschberger Bernhard Rupp Liane Fendt Valesca Bukur Irina Giese Patrick Sorn Ana Carolina Sant’Anna-Silva Javier Iglesias-Gonzalez Ugur Sahin Florian Kronenberg Erich Gnaiger Helmut Klocker
author_sort	Bernd Schöpf
title	OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
title_short	OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
title_full	OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
title_fullStr	OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
title_full_unstemmed	OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
title_sort	oxphos remodeling in high-grade prostate cancer involves mtdna mutations and increased succinate oxidation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f0501c636064d6cb8123ea16319c072
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OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

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