OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.

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Bibliographic Details
Main Authors: Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger, Helmut Klocker
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/5f0501c636064d6cb8123ea16319c072
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https://doaj.org/article/5f0501c636064d6cb8123ea16319c072

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