Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemi...

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Autores principales:	Pamela C. Rosato, Sathi Wijeyesinghe, J. Michael Stolley, Christine E. Nelson, Rachel L. Davis, Luke S. Manlove, Christopher A. Pennell, Bruce R. Blazar, Clark C. Chen, Melissa A. Geller, Vaiva Vezys, David Masopust
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f068cea4ece4349a43cb5cd50da3600
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spelling	oai:doaj.org-article:5f068cea4ece4349a43cb5cd50da36002021-12-02T16:51:00ZVirus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy10.1038/s41467-019-08534-12041-1723https://doaj.org/article/5f068cea4ece4349a43cb5cd50da36002019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08534-1https://doaj.org/toc/2041-1723The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemic anti-tumor immunity and synergize with checkpoint blockade.Pamela C. RosatoSathi WijeyesingheJ. Michael StolleyChristine E. NelsonRachel L. DavisLuke S. ManloveChristopher A. PennellBruce R. BlazarClark C. ChenMelissa A. GellerVaiva VezysDavid MasopustNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pamela C. Rosato Sathi Wijeyesinghe J. Michael Stolley Christine E. Nelson Rachel L. Davis Luke S. Manlove Christopher A. Pennell Bruce R. Blazar Clark C. Chen Melissa A. Geller Vaiva Vezys David Masopust Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
description	The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemic anti-tumor immunity and synergize with checkpoint blockade.
format	article
author	Pamela C. Rosato Sathi Wijeyesinghe J. Michael Stolley Christine E. Nelson Rachel L. Davis Luke S. Manlove Christopher A. Pennell Bruce R. Blazar Clark C. Chen Melissa A. Geller Vaiva Vezys David Masopust
author_facet	Pamela C. Rosato Sathi Wijeyesinghe J. Michael Stolley Christine E. Nelson Rachel L. Davis Luke S. Manlove Christopher A. Pennell Bruce R. Blazar Clark C. Chen Melissa A. Geller Vaiva Vezys David Masopust
author_sort	Pamela C. Rosato
title	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_short	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_full	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_fullStr	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_full_unstemmed	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_sort	virus-specific memory t cells populate tumors and can be repurposed for tumor immunotherapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5f068cea4ece4349a43cb5cd50da3600
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Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

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