Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis

Safaa AA Khaled,1 Eman NasrEldin,2 Yasmine S Makarem,3 Hamdy FF Mahmoud4,5 1Department of Internal Medicine, Clinical Hematology Unit, Assiut University Hospital/Unit of Bone Marrow Transplantation, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of C...

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Autores principales:	Khaled SAA, NasrEldin E, Makarem YS, Mahmoud HFF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rheumatoid arthritis platelet indices disease activity Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5f0b94cb3e4941338814b16aa940c1ae
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spelling	oai:doaj.org-article:5f0b94cb3e4941338814b16aa940c1ae2021-12-02T03:58:42ZValue of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis1178-7031https://doaj.org/article/5f0b94cb3e4941338814b16aa940c1ae2020-09-01T00:00:00Zhttps://www.dovepress.com/value-of-platelet-distribution-width-and-mean-platelet-volume-in-disea-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Safaa AA Khaled,1 Eman NasrEldin,2 Yasmine S Makarem,3 Hamdy FF Mahmoud4,5 1Department of Internal Medicine, Clinical Hematology Unit, Assiut University Hospital/Unit of Bone Marrow Transplantation, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of Clinical Pathology, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt; 3Department of Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt; 4Department of Statistics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA; 5Department of Statistics, Mathematics and Insurance, Faculty of Commerce, Assiut University, Assiut, EgyptCorrespondence: Safaa AA KhaledDepartment of Internal Medicine, Clinical Hematology Unit, Assiut University Hospital/Unit of Bone Marrow Transplantation, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut 71515, EgyptEmail safaakhaled2003@gmail.comBackground and Objective: Disease activity score 28 (DAS28) for rheumatoid arthritis (RA) is the commonly used DAS; it relies on clinical parameters that could be subjective. This work aimed to create a more accurate DAS for RA and assess its validity.Patients and Methods: The study included 98 RA patients and 53 matched controls; they were interviewed, clinically examined, their visual analogue scales (VAS) were reported, and then blood samples were withdrawn for erythrocyte sedimentation rate (ESR), complete blood count (CBC), and C-reactive protein (CRP). Platelet indices (PIs) were obtained from the CBC including Plt (platelet count), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). DAS28 was calculated for each patient using RheumaHelper mobile software. Minitab Statistical Package® and SPSS v20 software were used for data analysis.Results and Conclusions: Results revealed perfect matching between patients and controls as regarding age and gender. ESR, CRP and PDW were significantly higher in patients than controls; also positive correlations were detected among these variables. A new DAS for RA was developed; ESR, CRP, PDW and MPV were the components for this index. Further analyses showed that this new score was significantly higher in patients than controls and correlated with DAS28 of the patients. Furthermore the new score could identify RA patients from healthy subjects (cut off value < − 0.79) and stratified RA patients according to their disease activity into low, intermediate, high, or in remission. Conclusively, we developed a more precise, easily obtained new DAS for RA. This new DAS has both diagnostic/prognostic values in patients with RA.Keywords: rheumatoid arthritis, platelet indices, disease activityKhaled SAANasrEldin EMakarem YSMahmoud HFFDove Medical Pressarticlerheumatoid arthritisplatelet indicesdisease activityPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 595-606 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis platelet indices disease activity Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	rheumatoid arthritis platelet indices disease activity Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Khaled SAA NasrEldin E Makarem YS Mahmoud HFF Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
description	Safaa AA Khaled,1 Eman NasrEldin,2 Yasmine S Makarem,3 Hamdy FF Mahmoud4,5 1Department of Internal Medicine, Clinical Hematology Unit, Assiut University Hospital/Unit of Bone Marrow Transplantation, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt; 2Department of Clinical Pathology, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt; 3Department of Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt; 4Department of Statistics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA; 5Department of Statistics, Mathematics and Insurance, Faculty of Commerce, Assiut University, Assiut, EgyptCorrespondence: Safaa AA KhaledDepartment of Internal Medicine, Clinical Hematology Unit, Assiut University Hospital/Unit of Bone Marrow Transplantation, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut 71515, EgyptEmail safaakhaled2003@gmail.comBackground and Objective: Disease activity score 28 (DAS28) for rheumatoid arthritis (RA) is the commonly used DAS; it relies on clinical parameters that could be subjective. This work aimed to create a more accurate DAS for RA and assess its validity.Patients and Methods: The study included 98 RA patients and 53 matched controls; they were interviewed, clinically examined, their visual analogue scales (VAS) were reported, and then blood samples were withdrawn for erythrocyte sedimentation rate (ESR), complete blood count (CBC), and C-reactive protein (CRP). Platelet indices (PIs) were obtained from the CBC including Plt (platelet count), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). DAS28 was calculated for each patient using RheumaHelper mobile software. Minitab Statistical Package® and SPSS v20 software were used for data analysis.Results and Conclusions: Results revealed perfect matching between patients and controls as regarding age and gender. ESR, CRP and PDW were significantly higher in patients than controls; also positive correlations were detected among these variables. A new DAS for RA was developed; ESR, CRP, PDW and MPV were the components for this index. Further analyses showed that this new score was significantly higher in patients than controls and correlated with DAS28 of the patients. Furthermore the new score could identify RA patients from healthy subjects (cut off value < − 0.79) and stratified RA patients according to their disease activity into low, intermediate, high, or in remission. Conclusively, we developed a more precise, easily obtained new DAS for RA. This new DAS has both diagnostic/prognostic values in patients with RA.Keywords: rheumatoid arthritis, platelet indices, disease activity
format	article
author	Khaled SAA NasrEldin E Makarem YS Mahmoud HFF
author_facet	Khaled SAA NasrEldin E Makarem YS Mahmoud HFF
author_sort	Khaled SAA
title	Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
title_short	Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
title_full	Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
title_fullStr	Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
title_full_unstemmed	Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis
title_sort	value of platelet distribution width and mean platelet volume in disease activity score of rheumatoid arthritis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5f0b94cb3e4941338814b16aa940c1ae
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_version_	1718401490329010176

Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis

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