Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival

5p and 3p miRNA strands have different mRNA-targeting sequences and may both functionally impact gene expression in cancer. Here, the authors undertake a pan-cancer analysis that indicates 5p/3p miRNA strands function together to regulate tumorigenic processes.

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Autores principales:	Ramkrishna Mitra, Clare M. Adams, Wei Jiang, Evan Greenawalt, Christine M. Eischen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f0e591b78494b16971cad334299541c
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spelling	oai:doaj.org-article:5f0e591b78494b16971cad334299541c2021-12-02T17:31:25ZPan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival10.1038/s41467-020-14713-22041-1723https://doaj.org/article/5f0e591b78494b16971cad334299541c2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14713-2https://doaj.org/toc/2041-17235p and 3p miRNA strands have different mRNA-targeting sequences and may both functionally impact gene expression in cancer. Here, the authors undertake a pan-cancer analysis that indicates 5p/3p miRNA strands function together to regulate tumorigenic processes.Ramkrishna MitraClare M. AdamsWei JiangEvan GreenawaltChristine M. EischenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramkrishna Mitra Clare M. Adams Wei Jiang Evan Greenawalt Christine M. Eischen Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
description	5p and 3p miRNA strands have different mRNA-targeting sequences and may both functionally impact gene expression in cancer. Here, the authors undertake a pan-cancer analysis that indicates 5p/3p miRNA strands function together to regulate tumorigenic processes.
format	article
author	Ramkrishna Mitra Clare M. Adams Wei Jiang Evan Greenawalt Christine M. Eischen
author_facet	Ramkrishna Mitra Clare M. Adams Wei Jiang Evan Greenawalt Christine M. Eischen
author_sort	Ramkrishna Mitra
title	Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
title_short	Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
title_full	Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
title_fullStr	Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
title_full_unstemmed	Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
title_sort	pan-cancer analysis reveals cooperativity of both strands of microrna that regulate tumorigenesis and patient survival
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f0e591b78494b16971cad334299541c
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Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival

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