Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report

Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report

Masatake Kurita,1–3 Takahiro Moriya,2 Satoshi Nishino,2,4 Eishin Hirata,4 Noriyasu Hirasawa,5 Yoshiro Okubo,3 Tadahiro Sato4 1Wakamiya Hospital, Koutokukai, Yoshihara, Yamagata, 2Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyag...

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Autores principales: Kurita M, Moriya T, Nishino S, Hirata E, Hirasawa N, Okubo Y, Sato T
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
sleep disturbance
circadian rhythm sleep disorder
delayed sleep phase syndrome
treatment-resistant depression
pharmacotherapy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/5f11346bbc3243e1b49eb33966f87015
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spelling oai:doaj.org-article:5f11346bbc3243e1b49eb33966f870152021-12-02T06:47:20ZNon-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report1178-2021https://doaj.org/article/5f11346bbc3243e1b49eb33966f870152016-12-01T00:00:00Zhttps://www.dovepress.com/non-24-hour-sleepndashwake-syndrome-improved-by-low-dose-valproic-acid-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Masatake Kurita,1–3 Takahiro Moriya,2 Satoshi Nishino,2,4 Eishin Hirata,4 Noriyasu Hirasawa,5 Yoshiro Okubo,3 Tadahiro Sato4 1Wakamiya Hospital, Koutokukai, Yoshihara, Yamagata, 2Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 3Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Nippon Medical School, Sendagi, Tokyo, 4Sato Hospital, Koutokukai, Kunugizuka, Nanyo, Yamagata, 5Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan Abstract: A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms. Keywords: circadian rhythm sleep disorder, mood stabilizers, vitamin B12, melatonin, phototherapy, antidepressants, depressionKurita MMoriya TNishino SHirata EHirasawa NOkubo YSato TDove Medical Pressarticlesleep disturbancecircadian rhythm sleep disorderdelayed sleep phase syndrometreatment-resistant depressionpharmacotherapyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 3199-3203 (2016)
institution DOAJ
collection DOAJ
language EN
topic sleep disturbance
circadian rhythm sleep disorder
delayed sleep phase syndrome
treatment-resistant depression
pharmacotherapy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle sleep disturbance
circadian rhythm sleep disorder
delayed sleep phase syndrome
treatment-resistant depression
pharmacotherapy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Kurita M
Moriya T
Nishino S
Hirata E
Hirasawa N
Okubo Y
Sato T
Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
description Masatake Kurita,1–3 Takahiro Moriya,2 Satoshi Nishino,2,4 Eishin Hirata,4 Noriyasu Hirasawa,5 Yoshiro Okubo,3 Tadahiro Sato4 1Wakamiya Hospital, Koutokukai, Yoshihara, Yamagata, 2Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 3Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Nippon Medical School, Sendagi, Tokyo, 4Sato Hospital, Koutokukai, Kunugizuka, Nanyo, Yamagata, 5Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan Abstract: A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms. Keywords: circadian rhythm sleep disorder, mood stabilizers, vitamin B12, melatonin, phototherapy, antidepressants, depression
format article
author Kurita M
Moriya T
Nishino S
Hirata E
Hirasawa N
Okubo Y
Sato T
author_facet Kurita M
Moriya T
Nishino S
Hirata E
Hirasawa N
Okubo Y
Sato T
author_sort Kurita M
title Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_short Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_full Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_fullStr Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_full_unstemmed Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
title_sort non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/5f11346bbc3243e1b49eb33966f87015
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AT nishinos non24hoursleepndashwakesyndromeimprovedbylowdosevalproicacidacasereport
AT hiratae non24hoursleepndashwakesyndromeimprovedbylowdosevalproicacidacasereport
AT hirasawan non24hoursleepndashwakesyndromeimprovedbylowdosevalproicacidacasereport
AT okuboy non24hoursleepndashwakesyndromeimprovedbylowdosevalproicacidacasereport
AT satot non24hoursleepndashwakesyndromeimprovedbylowdosevalproicacidacasereport
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