Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery

Fengyi Du,*,1,2 Yunchao Wu,*,2 Fengting Du,*,3 Lirong Zhang,3 Weiwei Feng,4 Lulu Zhao,2 Rong Cai,3 Lixia Xu,2 Gaorui Bian,5 Jiangang Li,5 Shengqiang Zou,1 Aihua Gong,2 Miaomiao Zhang21Department of Hepatosis, The Affiliated Third Hospital of Zhenjiang, Jiangsu University, Zhenjiang 212013, People&am...

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Autores principales:	Du F, Wu Y, Zhang L, Feng W, Zhao L, Cai R, Xu L, Bian G, Li J, Zou S, Gong A, Zhang M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Catechol Mucoadhesive Microcapsules CT imaging Gastroretentive drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5f118c93670c49fa9a722916235974ff
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spelling	oai:doaj.org-article:5f118c93670c49fa9a722916235974ff2021-12-02T01:59:51ZConstruction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery1178-2013https://doaj.org/article/5f118c93670c49fa9a722916235974ff2019-07-01T00:00:00Zhttps://www.dovepress.com/construction-of-catechol-grafted-chitosan-alginatebarium-sulfate-micro-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fengyi Du,,1,2 Yunchao Wu,,2 Fengting Du,,3 Lirong Zhang,3 Weiwei Feng,4 Lulu Zhao,2 Rong Cai,3 Lixia Xu,2 Gaorui Bian,5 Jiangang Li,5 Shengqiang Zou,1 Aihua Gong,2 Miaomiao Zhang21Department of Hepatosis, The Affiliated Third Hospital of Zhenjiang, Jiangsu University, Zhenjiang 212013, People’s Republic of China; 2School of Medicine, Jiangsu University, Zhenjiang 212013, People’s Republic of China; 3Department of Physiotherapy, Huangnihe Town Hospital, Huangnihe 133704, People’s Republic of China; 4School of Environmental and Safety Engineering, Jiangsu University, Zhenjiang 212013, People’s Republic of China; 5Tianyi Health Sciences Institute (Zhenjiang) Co. Ltd, Zhenjiang 212013, People’s Republic of ChinaThese authors contributed equally to this workBackground: The gastroretentive drug delivery system is an effective administration route, which can improve the bioavailability of the drug and the therapeutic effect by prolonging the release time of the drug and controlling the release rate in the stomach.Methods: Inspired by the excellent adhesion properties of mussel protein, we prepared novel catechol-grafted chitosan alginate/barium sulfate microcapsules (Cat-CA/BS MCs) with mucoadhesive properties and computed tomography (CT) imaging function for gastric drug delivery. First, barium sulfate nanoclusters used as CT contrast agent were synthesized in situ in the Cat-CA/BS MCs through a one-step electronic spinning method. Next, catechol-grafted chitosan as the mucoadhesive moiety was coated on the surface of Cat-CA/BS MCs by polyelectrolyte molecule self-assembly.Results: The prepared Cat-CA/BS MCs could effectively retained in the stomach for 48 hours and successively released ranitidine hydrochloride, which could be used for the treatment of gastric ulcer. Cat-CA/BS MCs exhibited superior CT contrast imaging properties for real-time tracking in vivo after oral administration.Conclusion: These findings demonstrate that Cat-CA/BS MCs serving as multifunctional oral drug carriers possess huge potential in gastroretentive drug delivery and non-invasive visualization.Keywords: catechol, mucoadhesive, microcapsules, CT imaging, gastroretentive drug deliveryDu FWu YDu FZhang LFeng WZhao LCai RXu LBian GLi JZou SGong AZhang MDove Medical PressarticleCatecholMucoadhesiveMicrocapsulesCT imagingGastroretentive drug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 6001-6018 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Catechol Mucoadhesive Microcapsules CT imaging Gastroretentive drug delivery Medicine (General) R5-920
spellingShingle	Catechol Mucoadhesive Microcapsules CT imaging Gastroretentive drug delivery Medicine (General) R5-920 Du F Wu Y Du F Zhang L Feng W Zhao L Cai R Xu L Bian G Li J Zou S Gong A Zhang M Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
description	Fengyi Du,,1,2 Yunchao Wu,,2 Fengting Du,,3 Lirong Zhang,3 Weiwei Feng,4 Lulu Zhao,2 Rong Cai,3 Lixia Xu,2 Gaorui Bian,5 Jiangang Li,5 Shengqiang Zou,1 Aihua Gong,2 Miaomiao Zhang21Department of Hepatosis, The Affiliated Third Hospital of Zhenjiang, Jiangsu University, Zhenjiang 212013, People’s Republic of China; 2School of Medicine, Jiangsu University, Zhenjiang 212013, People’s Republic of China; 3Department of Physiotherapy, Huangnihe Town Hospital, Huangnihe 133704, People’s Republic of China; 4School of Environmental and Safety Engineering, Jiangsu University, Zhenjiang 212013, People’s Republic of China; 5Tianyi Health Sciences Institute (Zhenjiang) Co. Ltd, Zhenjiang 212013, People’s Republic of ChinaThese authors contributed equally to this workBackground: The gastroretentive drug delivery system is an effective administration route, which can improve the bioavailability of the drug and the therapeutic effect by prolonging the release time of the drug and controlling the release rate in the stomach.Methods: Inspired by the excellent adhesion properties of mussel protein, we prepared novel catechol-grafted chitosan alginate/barium sulfate microcapsules (Cat-CA/BS MCs) with mucoadhesive properties and computed tomography (CT) imaging function for gastric drug delivery. First, barium sulfate nanoclusters used as CT contrast agent were synthesized in situ in the Cat-CA/BS MCs through a one-step electronic spinning method. Next, catechol-grafted chitosan as the mucoadhesive moiety was coated on the surface of Cat-CA/BS MCs by polyelectrolyte molecule self-assembly.Results: The prepared Cat-CA/BS MCs could effectively retained in the stomach for 48 hours and successively released ranitidine hydrochloride, which could be used for the treatment of gastric ulcer. Cat-CA/BS MCs exhibited superior CT contrast imaging properties for real-time tracking in vivo after oral administration.Conclusion: These findings demonstrate that Cat-CA/BS MCs serving as multifunctional oral drug carriers possess huge potential in gastroretentive drug delivery and non-invasive visualization.Keywords: catechol, mucoadhesive, microcapsules, CT imaging, gastroretentive drug delivery
format	article
author	Du F Wu Y Du F Zhang L Feng W Zhao L Cai R Xu L Bian G Li J Zou S Gong A Zhang M
author_facet	Du F Wu Y Du F Zhang L Feng W Zhao L Cai R Xu L Bian G Li J Zou S Gong A Zhang M
author_sort	Du F
title	Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
title_short	Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
title_full	Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
title_fullStr	Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
title_full_unstemmed	Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
title_sort	construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5f118c93670c49fa9a722916235974ff
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Construction of catechol-grafted chitosan alginate/barium sulfate microcapsules for computed tomography real-time imaging and gastroretentive drug delivery

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