Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches

The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-moda...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	C. Batson, A. Gomez, A. S. Sainbhi, L. Froese, F. A. Zeiler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging cerebral physiology sex TBI - traumatic brain injury traumatic brain injury (craniocerebral trauma) Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5f1205686bc9447a8be2009e072729e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5f1205686bc9447a8be2009e072729e3
record_format	dspace
spelling	oai:doaj.org-article:5f1205686bc9447a8be2009e072729e32021-11-30T18:44:57ZAssociation of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches1663-981210.3389/fphar.2021.676154https://doaj.org/article/5f1205686bc9447a8be2009e072729e32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.676154/fullhttps://doaj.org/toc/1663-9812The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-modal monitoring (MMM) cerebral physiology is unclear, with only sparing reference made in guidelines and major literature in moderate/severe TBI. In this narrative review, we summarize some of the largest studies associating various high-frequency MMM parameters with age and biological sex in moderate/severe TBI. To start, we present this by highlighting the representative available literature on high-frequency data from Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Extracellular Brain Tissue Oxygenation (PbtO2), Regional Cerebral Oxygen Saturations (rSO2), Cerebral Blood Flow (CBF), Cerebral Blood Flow Velocity (CBFV), Cerebrovascular Reactivity (CVR), Cerebral Compensatory Reserve, common Cerebral Microdialysis (CMD) Analytes and their correlation to age and sex in moderate/severe TBI cohorts. Then we present current knowledge gaps in the literature, discuss biological implications of age and sex on cerebrovascular monitoring in TBI and some future avenues for bedside research into the cerebrovascular physiome after TBI.C. BatsonA. GomezA. GomezA. S. SainbhiL. FroeseF. A. ZeilerF. A. ZeilerF. A. ZeilerF. A. ZeilerF. A. ZeilerFrontiers Media S.A.articleagingcerebral physiologysexTBI - traumatic brain injurytraumatic brain injury (craniocerebral trauma)Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging cerebral physiology sex TBI - traumatic brain injury traumatic brain injury (craniocerebral trauma) Therapeutics. Pharmacology RM1-950
spellingShingle	aging cerebral physiology sex TBI - traumatic brain injury traumatic brain injury (craniocerebral trauma) Therapeutics. Pharmacology RM1-950 C. Batson A. Gomez A. Gomez A. S. Sainbhi L. Froese F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
description	The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the association between age/biological sex and high-frequency continuous multi-modal monitoring (MMM) cerebral physiology is unclear, with only sparing reference made in guidelines and major literature in moderate/severe TBI. In this narrative review, we summarize some of the largest studies associating various high-frequency MMM parameters with age and biological sex in moderate/severe TBI. To start, we present this by highlighting the representative available literature on high-frequency data from Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP), Extracellular Brain Tissue Oxygenation (PbtO2), Regional Cerebral Oxygen Saturations (rSO2), Cerebral Blood Flow (CBF), Cerebral Blood Flow Velocity (CBFV), Cerebrovascular Reactivity (CVR), Cerebral Compensatory Reserve, common Cerebral Microdialysis (CMD) Analytes and their correlation to age and sex in moderate/severe TBI cohorts. Then we present current knowledge gaps in the literature, discuss biological implications of age and sex on cerebrovascular monitoring in TBI and some future avenues for bedside research into the cerebrovascular physiome after TBI.
format	article
author	C. Batson A. Gomez A. Gomez A. S. Sainbhi L. Froese F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler
author_facet	C. Batson A. Gomez A. Gomez A. S. Sainbhi L. Froese F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler F. A. Zeiler
author_sort	C. Batson
title	Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
title_short	Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
title_full	Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
title_fullStr	Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
title_full_unstemmed	Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches
title_sort	association of age and sex with multi-modal cerebral physiology in adult moderate/severe traumatic brain injury: a narrative overview and future avenues for personalized approaches
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5f1205686bc9447a8be2009e072729e3
work_keys_str_mv	AT cbatson associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT agomez associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT agomez associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT assainbhi associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT lfroese associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT fazeiler associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT fazeiler associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT fazeiler associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT fazeiler associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches AT fazeiler associationofageandsexwithmultimodalcerebralphysiologyinadultmoderateseveretraumaticbraininjuryanarrativeoverviewandfutureavenuesforpersonalizedapproaches
_version_	1718406325999763456

Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury: A Narrative Overview and Future Avenues for Personalized Approaches

Ejemplares similares