Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections

Abstract Antimicrobial resistance (AMR) surveillance in bloodstream infections (BSIs) is challenging in low/middle-income countries (LMICs) given limited laboratory capacity. Other specimens are easier to collect and process and are more likely to be culture-positive. In 8102 E. coli BSIs, 322,087 E...

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Autores principales:	Karina-Doris Vihta, Nicola Claire Gordon, Nicole Stoesser, T. Phuong Quan, Carina S. B. Tyrrell, Manivanh Vongsouvath, Elizabeth A. Ashley, Vilada Chansamouth, Paul Turner, Clare L. Ling, David W. Eyre, Nicholas J. White, Derrick Crook, Tim E. A. Peto, Ann Sarah Walker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f1389af6a784f24aed4d5da9685eb32
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spelling	oai:doaj.org-article:5f1389af6a784f24aed4d5da9685eb322021-12-05T12:15:18ZAntimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections10.1038/s41598-021-02755-52045-2322https://doaj.org/article/5f1389af6a784f24aed4d5da9685eb322021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02755-5https://doaj.org/toc/2045-2322Abstract Antimicrobial resistance (AMR) surveillance in bloodstream infections (BSIs) is challenging in low/middle-income countries (LMICs) given limited laboratory capacity. Other specimens are easier to collect and process and are more likely to be culture-positive. In 8102 E. coli BSIs, 322,087 E. coli urinary tract infections, 6952 S. aureus BSIs and 112,074 S. aureus non-sterile site cultures from Oxfordshire (1998–2018), and other (55,296 isolates) rarer commensal opportunistic pathogens, antibiotic resistance trends over time in blood were strongly associated with those in other specimens (maximum cross-correlation per drug 0.51–0.99). Resistance prevalence was congruent across drug-years for each species (276/312 (88%) species-drug-years with prevalence within ± 10% between blood/other isolates). Results were similar across multiple countries in high/middle/low income-settings in the independent ATLAS dataset (103,559 isolates, 2004–2017) and three further LMIC hospitals/programmes (6154 isolates, 2008–2019). AMR in commensal opportunistic pathogens cultured from BSIs is strongly associated with AMR in commensal opportunistic pathogens cultured from non-sterile sites over calendar time, suggesting the latter could be used as an effective proxy for AMR surveillance in BSIs.Karina-Doris VihtaNicola Claire GordonNicole StoesserT. Phuong QuanCarina S. B. TyrrellManivanh VongsouvathElizabeth A. AshleyVilada ChansamouthPaul TurnerClare L. LingDavid W. EyreNicholas J. WhiteDerrick CrookTim E. A. PetoAnn Sarah WalkerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karina-Doris Vihta Nicola Claire Gordon Nicole Stoesser T. Phuong Quan Carina S. B. Tyrrell Manivanh Vongsouvath Elizabeth A. Ashley Vilada Chansamouth Paul Turner Clare L. Ling David W. Eyre Nicholas J. White Derrick Crook Tim E. A. Peto Ann Sarah Walker Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
description	Abstract Antimicrobial resistance (AMR) surveillance in bloodstream infections (BSIs) is challenging in low/middle-income countries (LMICs) given limited laboratory capacity. Other specimens are easier to collect and process and are more likely to be culture-positive. In 8102 E. coli BSIs, 322,087 E. coli urinary tract infections, 6952 S. aureus BSIs and 112,074 S. aureus non-sterile site cultures from Oxfordshire (1998–2018), and other (55,296 isolates) rarer commensal opportunistic pathogens, antibiotic resistance trends over time in blood were strongly associated with those in other specimens (maximum cross-correlation per drug 0.51–0.99). Resistance prevalence was congruent across drug-years for each species (276/312 (88%) species-drug-years with prevalence within ± 10% between blood/other isolates). Results were similar across multiple countries in high/middle/low income-settings in the independent ATLAS dataset (103,559 isolates, 2004–2017) and three further LMIC hospitals/programmes (6154 isolates, 2008–2019). AMR in commensal opportunistic pathogens cultured from BSIs is strongly associated with AMR in commensal opportunistic pathogens cultured from non-sterile sites over calendar time, suggesting the latter could be used as an effective proxy for AMR surveillance in BSIs.
format	article
author	Karina-Doris Vihta Nicola Claire Gordon Nicole Stoesser T. Phuong Quan Carina S. B. Tyrrell Manivanh Vongsouvath Elizabeth A. Ashley Vilada Chansamouth Paul Turner Clare L. Ling David W. Eyre Nicholas J. White Derrick Crook Tim E. A. Peto Ann Sarah Walker
author_facet	Karina-Doris Vihta Nicola Claire Gordon Nicole Stoesser T. Phuong Quan Carina S. B. Tyrrell Manivanh Vongsouvath Elizabeth A. Ashley Vilada Chansamouth Paul Turner Clare L. Ling David W. Eyre Nicholas J. White Derrick Crook Tim E. A. Peto Ann Sarah Walker
author_sort	Karina-Doris Vihta
title	Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
title_short	Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
title_full	Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
title_fullStr	Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
title_full_unstemmed	Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
title_sort	antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f1389af6a784f24aed4d5da9685eb32
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Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections

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