Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

Using spheroids as a model, the authors report the molecular signatures of ovarian surface epithelial (OSE) cells exhibiting stemness phenotype under various conditions in vitro, and found that there is a large degree of heterogeneity in the transcriptional profiles of stem cells induced under diffe...

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Autores principales:	Lauren E. Carter, David P. Cook, Curtis W. McCloskey, Melanie A. Grondin, David A. Landry, Tiffany Dang, Olga Collins, Lisa F. Gamwell, Holly A. Dempster, Barbara C. Vanderhyden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5f145f98c5094ea0a4fc11d945bb767c
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spelling	oai:doaj.org-article:5f145f98c5094ea0a4fc11d945bb767c2021-12-02T14:49:33ZTranscriptional heterogeneity of stemness phenotypes in the ovarian epithelium10.1038/s42003-021-02045-w2399-3642https://doaj.org/article/5f145f98c5094ea0a4fc11d945bb767c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02045-whttps://doaj.org/toc/2399-3642Using spheroids as a model, the authors report the molecular signatures of ovarian surface epithelial (OSE) cells exhibiting stemness phenotype under various conditions in vitro, and found that there is a large degree of heterogeneity in the transcriptional profiles of stem cells induced under different conditions. They suggest that maintenance of the OSE may not require a single stem cell population, but heterogeneous stem cells that can be induced transiently under diverse environmental cues.Lauren E. CarterDavid P. CookCurtis W. McCloskeyMelanie A. GrondinDavid A. LandryTiffany DangOlga CollinsLisa F. GamwellHolly A. DempsterBarbara C. VanderhydenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lauren E. Carter David P. Cook Curtis W. McCloskey Melanie A. Grondin David A. Landry Tiffany Dang Olga Collins Lisa F. Gamwell Holly A. Dempster Barbara C. Vanderhyden Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
description	Using spheroids as a model, the authors report the molecular signatures of ovarian surface epithelial (OSE) cells exhibiting stemness phenotype under various conditions in vitro, and found that there is a large degree of heterogeneity in the transcriptional profiles of stem cells induced under different conditions. They suggest that maintenance of the OSE may not require a single stem cell population, but heterogeneous stem cells that can be induced transiently under diverse environmental cues.
format	article
author	Lauren E. Carter David P. Cook Curtis W. McCloskey Melanie A. Grondin David A. Landry Tiffany Dang Olga Collins Lisa F. Gamwell Holly A. Dempster Barbara C. Vanderhyden
author_facet	Lauren E. Carter David P. Cook Curtis W. McCloskey Melanie A. Grondin David A. Landry Tiffany Dang Olga Collins Lisa F. Gamwell Holly A. Dempster Barbara C. Vanderhyden
author_sort	Lauren E. Carter
title	Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
title_short	Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
title_full	Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
title_fullStr	Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
title_full_unstemmed	Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
title_sort	transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f145f98c5094ea0a4fc11d945bb767c
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Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

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