The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States

Ying Huang,1,* Ying Jiang,2,* Meilan Zhu2 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jia...

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Autores principales:	Huang Y, Jiang Y, Zhu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	global sleep score inflammation body mass index perceived stress obese adults Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/5f1742e294914f9693d8f14ae0c9c2fe
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spelling	oai:doaj.org-article:5f1742e294914f9693d8f14ae0c9c2fe2021-12-02T09:23:21ZThe Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States1179-1608https://doaj.org/article/5f1742e294914f9693d8f14ae0c9c2fe2019-11-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-global-sleep-score-and-inflammatory-markers-i-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Ying Huang,1,* Ying Jiang,2,* Meilan Zhu2 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meilan ZhuDepartment of Rehabilitation, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, Jiangxi 330006, People’s Republic of ChinaEmail 15070896289@139.comBackground: Poor sleep is a risk factor for cardiovascular diseases (CVDs). The underlying pathogenesis is not clear. Levels of inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-ɑ (TNF-ɑ), have been found to be elevated in patients with CVDs.Aim: The study aimed to investigate the associations between sleep quality and serum inflammatory markers in a cohort of obese adults.Methods: This was a second analysis of the data from the Midlife in the United States (MIDUS) study, a longitudinal study of a national (US) sample of adults. A total of 1255 participants completed comprehensive biological assessments. The associations between global sleep score and serum levels of inflammatory markers were analyzed.Results: Univariate analysis showed that a higher global sleep score was correlated with lower age (r = −0.079, P= 0.009), higher BMI (r = 0.100, P= 0.001) and heavier perceived stress (r = 0.335, P<0.001). Multivariate linear regression analysis showed that the global sleep score was positively related to levels of IL-6 (Sβ=0.074, P=0.009), IL-8 (Sβ=0.089, P=0.002), TNF-ɑ (Sβ=0.0.082, P=0.005), E-selectin (Sβ=0.071, P=0.016) and intercellular adhesion molecule-1 (ICAM-1, Sβ=0.117, P<0.001) after adjustments were made for age, gender, race, marital status, education, current smoking status, physician-diagnosed CVDs and respiratory diseases, BMI and perceived stress. However, the global sleep score was not associated with serum IL-10 (Sβ=−0.021, P=0.463) and CRP (Sβ=0.035, P=0.059) levels after adjustments were made for these confounding factors.Conclusion: Poor sleep is positively associated with serum inflammatory marker levels among obese adults. Sufficient sleep may be particularly important for obese adults to prevent CVDs.Keywords: global sleep score, inflammation, body mass index, perceived stress, obese adultsHuang YJiang YZhu MDove Medical Pressarticleglobal sleep scoreinflammationbody mass indexperceived stressobese adultsPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 11, Pp 317-324 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	global sleep score inflammation body mass index perceived stress obese adults Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	global sleep score inflammation body mass index perceived stress obese adults Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Huang Y Jiang Y Zhu M The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States
description	Ying Huang,1,* Ying Jiang,2,* Meilan Zhu2 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meilan ZhuDepartment of Rehabilitation, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, Jiangxi 330006, People’s Republic of ChinaEmail 15070896289@139.comBackground: Poor sleep is a risk factor for cardiovascular diseases (CVDs). The underlying pathogenesis is not clear. Levels of inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-ɑ (TNF-ɑ), have been found to be elevated in patients with CVDs.Aim: The study aimed to investigate the associations between sleep quality and serum inflammatory markers in a cohort of obese adults.Methods: This was a second analysis of the data from the Midlife in the United States (MIDUS) study, a longitudinal study of a national (US) sample of adults. A total of 1255 participants completed comprehensive biological assessments. The associations between global sleep score and serum levels of inflammatory markers were analyzed.Results: Univariate analysis showed that a higher global sleep score was correlated with lower age (r = −0.079, P= 0.009), higher BMI (r = 0.100, P= 0.001) and heavier perceived stress (r = 0.335, P<0.001). Multivariate linear regression analysis showed that the global sleep score was positively related to levels of IL-6 (Sβ=0.074, P=0.009), IL-8 (Sβ=0.089, P=0.002), TNF-ɑ (Sβ=0.0.082, P=0.005), E-selectin (Sβ=0.071, P=0.016) and intercellular adhesion molecule-1 (ICAM-1, Sβ=0.117, P<0.001) after adjustments were made for age, gender, race, marital status, education, current smoking status, physician-diagnosed CVDs and respiratory diseases, BMI and perceived stress. However, the global sleep score was not associated with serum IL-10 (Sβ=−0.021, P=0.463) and CRP (Sβ=0.035, P=0.059) levels after adjustments were made for these confounding factors.Conclusion: Poor sleep is positively associated with serum inflammatory marker levels among obese adults. Sufficient sleep may be particularly important for obese adults to prevent CVDs.Keywords: global sleep score, inflammation, body mass index, perceived stress, obese adults
format	article
author	Huang Y Jiang Y Zhu M
author_facet	Huang Y Jiang Y Zhu M
author_sort	Huang Y
title	The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States
title_short	The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States
title_full	The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States
title_fullStr	The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States
title_full_unstemmed	The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States
title_sort	relationship between global sleep score and inflammatory markers in obese adults from the united states
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5f1742e294914f9693d8f14ae0c9c2fe
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The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States

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