Genomic profile of advanced breast cancer in circulating tumour DNA

Circulating tumour DNA can provide useful information on disease burden. Here, the authors analysed circulating tumour DNA from 800 patients from a breast cancer clinical trial and investigate the subclonal nature of the disease, and identify DNA mutations associated with resistance and poor surviva...

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Autores principales:	Belinda Kingston, Rosalind J. Cutts, Hannah Bye, Matthew Beaney, Giselle Walsh-Crestani, Sarah Hrebien, Claire Swift, Lucy S. Kilburn, Sarah Kernaghan, Laura Moretti, Katie Wilkinson, Andrew M. Wardley, Iain R. Macpherson, Richard D. Baird, Rebecca Roylance, Jorge S. Reis-Filho, Michael Hubank, Iris Faull, Kimberly C. Banks, Richard B. Lanman, Isaac Garcia-Murillas, Judith M. Bliss, Alistair Ring, Nicholas C. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f176e5d5bcb4792adb4ec1effb35966
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spelling	oai:doaj.org-article:5f176e5d5bcb4792adb4ec1effb359662021-12-02T17:33:33ZGenomic profile of advanced breast cancer in circulating tumour DNA10.1038/s41467-021-22605-22041-1723https://doaj.org/article/5f176e5d5bcb4792adb4ec1effb359662021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22605-2https://doaj.org/toc/2041-1723Circulating tumour DNA can provide useful information on disease burden. Here, the authors analysed circulating tumour DNA from 800 patients from a breast cancer clinical trial and investigate the subclonal nature of the disease, and identify DNA mutations associated with resistance and poor survival.Belinda KingstonRosalind J. CuttsHannah ByeMatthew BeaneyGiselle Walsh-CrestaniSarah HrebienClaire SwiftLucy S. KilburnSarah KernaghanLaura MorettiKatie WilkinsonAndrew M. WardleyIain R. MacphersonRichard D. BairdRebecca RoylanceJorge S. Reis-FilhoMichael HubankIris FaullKimberly C. BanksRichard B. LanmanIsaac Garcia-MurillasJudith M. BlissAlistair RingNicholas C. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Belinda Kingston Rosalind J. Cutts Hannah Bye Matthew Beaney Giselle Walsh-Crestani Sarah Hrebien Claire Swift Lucy S. Kilburn Sarah Kernaghan Laura Moretti Katie Wilkinson Andrew M. Wardley Iain R. Macpherson Richard D. Baird Rebecca Roylance Jorge S. Reis-Filho Michael Hubank Iris Faull Kimberly C. Banks Richard B. Lanman Isaac Garcia-Murillas Judith M. Bliss Alistair Ring Nicholas C. Turner Genomic profile of advanced breast cancer in circulating tumour DNA
description	Circulating tumour DNA can provide useful information on disease burden. Here, the authors analysed circulating tumour DNA from 800 patients from a breast cancer clinical trial and investigate the subclonal nature of the disease, and identify DNA mutations associated with resistance and poor survival.
format	article
author	Belinda Kingston Rosalind J. Cutts Hannah Bye Matthew Beaney Giselle Walsh-Crestani Sarah Hrebien Claire Swift Lucy S. Kilburn Sarah Kernaghan Laura Moretti Katie Wilkinson Andrew M. Wardley Iain R. Macpherson Richard D. Baird Rebecca Roylance Jorge S. Reis-Filho Michael Hubank Iris Faull Kimberly C. Banks Richard B. Lanman Isaac Garcia-Murillas Judith M. Bliss Alistair Ring Nicholas C. Turner
author_facet	Belinda Kingston Rosalind J. Cutts Hannah Bye Matthew Beaney Giselle Walsh-Crestani Sarah Hrebien Claire Swift Lucy S. Kilburn Sarah Kernaghan Laura Moretti Katie Wilkinson Andrew M. Wardley Iain R. Macpherson Richard D. Baird Rebecca Roylance Jorge S. Reis-Filho Michael Hubank Iris Faull Kimberly C. Banks Richard B. Lanman Isaac Garcia-Murillas Judith M. Bliss Alistair Ring Nicholas C. Turner
author_sort	Belinda Kingston
title	Genomic profile of advanced breast cancer in circulating tumour DNA
title_short	Genomic profile of advanced breast cancer in circulating tumour DNA
title_full	Genomic profile of advanced breast cancer in circulating tumour DNA
title_fullStr	Genomic profile of advanced breast cancer in circulating tumour DNA
title_full_unstemmed	Genomic profile of advanced breast cancer in circulating tumour DNA
title_sort	genomic profile of advanced breast cancer in circulating tumour dna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f176e5d5bcb4792adb4ec1effb35966
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Genomic profile of advanced breast cancer in circulating tumour DNA

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