Sign epistasis caused by hierarchy within signalling cascades

Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy between signalling cascade components.

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Detalles Bibliográficos
Autores principales:	Philippe Nghe, Manjunatha Kogenaru, Sander J. Tans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f1ac5638b4b4c4ea6b6271404db04df
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spelling	oai:doaj.org-article:5f1ac5638b4b4c4ea6b6271404db04df2021-12-02T16:49:18ZSign epistasis caused by hierarchy within signalling cascades10.1038/s41467-018-03644-82041-1723https://doaj.org/article/5f1ac5638b4b4c4ea6b6271404db04df2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03644-8https://doaj.org/toc/2041-1723Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy between signalling cascade components.Philippe NgheManjunatha KogenaruSander J. TansNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philippe Nghe Manjunatha Kogenaru Sander J. Tans Sign epistasis caused by hierarchy within signalling cascades
description	Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy between signalling cascade components.
format	article
author	Philippe Nghe Manjunatha Kogenaru Sander J. Tans
author_facet	Philippe Nghe Manjunatha Kogenaru Sander J. Tans
author_sort	Philippe Nghe
title	Sign epistasis caused by hierarchy within signalling cascades
title_short	Sign epistasis caused by hierarchy within signalling cascades
title_full	Sign epistasis caused by hierarchy within signalling cascades
title_fullStr	Sign epistasis caused by hierarchy within signalling cascades
title_full_unstemmed	Sign epistasis caused by hierarchy within signalling cascades
title_sort	sign epistasis caused by hierarchy within signalling cascades
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5f1ac5638b4b4c4ea6b6271404db04df
work_keys_str_mv	AT philippenghe signepistasiscausedbyhierarchywithinsignallingcascades AT manjunathakogenaru signepistasiscausedbyhierarchywithinsignallingcascades AT sanderjtans signepistasiscausedbyhierarchywithinsignallingcascades
_version_	1718383335749713920

Sign epistasis caused by hierarchy within signalling cascades

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