Triacylglycerols sequester monotopic membrane proteins to lipid droplets

Triacylglycerols sequester monotopic membrane proteins to lipid droplets

Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into monolayer lipid droplets (LDs), but how proteins partition between ER and LDs is poorly understood. Here authors use synthetic model systems and find that proteins containing hydrophobic membrane associ...

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Autores principales: Lucie Caillon, Vincent Nieto, Pauline Gehan, Mohyeddine Omrane, Nicolas Rodriguez, Luca Monticelli, Abdou Rachid Thiam
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5f1c4d552ae7432cbfd5fbb8de490279
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spelling oai:doaj.org-article:5f1c4d552ae7432cbfd5fbb8de4902792021-12-02T16:35:19ZTriacylglycerols sequester monotopic membrane proteins to lipid droplets10.1038/s41467-020-17585-82041-1723https://doaj.org/article/5f1c4d552ae7432cbfd5fbb8de4902792020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17585-8https://doaj.org/toc/2041-1723Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into monolayer lipid droplets (LDs), but how proteins partition between ER and LDs is poorly understood. Here authors use synthetic model systems and find that proteins containing hydrophobic membrane association domains strongly prefer monolayers and that returning to the bilayer is unfavorable.Lucie CaillonVincent NietoPauline GehanMohyeddine OmraneNicolas RodriguezLuca MonticelliAbdou Rachid ThiamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lucie Caillon
Vincent Nieto
Pauline Gehan
Mohyeddine Omrane
Nicolas Rodriguez
Luca Monticelli
Abdou Rachid Thiam
Triacylglycerols sequester monotopic membrane proteins to lipid droplets
description Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into monolayer lipid droplets (LDs), but how proteins partition between ER and LDs is poorly understood. Here authors use synthetic model systems and find that proteins containing hydrophobic membrane association domains strongly prefer monolayers and that returning to the bilayer is unfavorable.
format article
author Lucie Caillon
Vincent Nieto
Pauline Gehan
Mohyeddine Omrane
Nicolas Rodriguez
Luca Monticelli
Abdou Rachid Thiam
author_facet Lucie Caillon
Vincent Nieto
Pauline Gehan
Mohyeddine Omrane
Nicolas Rodriguez
Luca Monticelli
Abdou Rachid Thiam
author_sort Lucie Caillon
title Triacylglycerols sequester monotopic membrane proteins to lipid droplets
title_short Triacylglycerols sequester monotopic membrane proteins to lipid droplets
title_full Triacylglycerols sequester monotopic membrane proteins to lipid droplets
title_fullStr Triacylglycerols sequester monotopic membrane proteins to lipid droplets
title_full_unstemmed Triacylglycerols sequester monotopic membrane proteins to lipid droplets
title_sort triacylglycerols sequester monotopic membrane proteins to lipid droplets
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/5f1c4d552ae7432cbfd5fbb8de490279
work_keys_str_mv AT luciecaillon triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
AT vincentnieto triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
AT paulinegehan triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
AT mohyeddineomrane triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
AT nicolasrodriguez triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
AT lucamonticelli triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
AT abdourachidthiam triacylglycerolssequestermonotopicmembraneproteinstolipiddroplets
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