In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta

Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteo...

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Autores principales:	Kobayashi A, Higashide T, Yokogawa H, Yamazaki N, Masaki T, Sugiyama K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5f285e4932a243448f7e9e7889f749ff
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spelling	oai:doaj.org-article:5f285e4932a243448f7e9e7889f749ff2021-12-02T05:19:14ZIn vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta1177-5483https://doaj.org/article/5f285e4932a243448f7e9e7889f749ff2014-02-01T00:00:00Zhttp://www.dovepress.com/in-vivo-laser-confocal-microscopy-findings-of-a-cornea-with-osteogenes-a15911https://doaj.org/toc/1177-5483 Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI) with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures). Patients and methods: Two patients (67-year-old male and his 26-year-old son) with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD) (the right eye) and 384 µm oculus sinister (OS) (the left eye) in the father and 430 µm OD and 425 µm OS in the son). In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layerKobayashi AHigashide TYokogawa HYamazaki NMasaki TSugiyama KDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 429-433 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kobayashi A Higashide T Yokogawa H Yamazaki N Masaki T Sugiyama K In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
description	Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI) with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures). Patients and methods: Two patients (67-year-old male and his 26-year-old son) with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD) (the right eye) and 384 µm oculus sinister (OS) (the left eye) in the father and 430 µm OD and 425 µm OS in the son). In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layer
format	article
author	Kobayashi A Higashide T Yokogawa H Yamazaki N Masaki T Sugiyama K
author_facet	Kobayashi A Higashide T Yokogawa H Yamazaki N Masaki T Sugiyama K
author_sort	Kobayashi A
title	In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_short	In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_full	In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_fullStr	In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_full_unstemmed	In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_sort	in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/5f285e4932a243448f7e9e7889f749ff
work_keys_str_mv	AT kobayashia invivolaserconfocalmicroscopyfindingsofacorneawithosteogenesisimperfecta AT higashidet invivolaserconfocalmicroscopyfindingsofacorneawithosteogenesisimperfecta AT yokogawah invivolaserconfocalmicroscopyfindingsofacorneawithosteogenesisimperfecta AT yamazakin invivolaserconfocalmicroscopyfindingsofacorneawithosteogenesisimperfecta AT masakit invivolaserconfocalmicroscopyfindingsofacorneawithosteogenesisimperfecta AT sugiyamak invivolaserconfocalmicroscopyfindingsofacorneawithosteogenesisimperfecta
_version_	1718400472026447872

In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta

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