The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection

Abstract Background Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified. Methods We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital fro...

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Autores principales:	Hiroki Mukoyama, Mirei Shirakashi, Nozomi Tanaka, Takeshi Iwasaki, Toshiki Nakajima, Hideo Onizawa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Masao Tanaka, Akio Morinobu, Hajime Yoshifuji
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Takayasu arteritis Pulmonary artery involvement Ischemic heart diseases Infection Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/5f28c73e92f64a95abaa15482ad0e71e
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spelling	oai:doaj.org-article:5f28c73e92f64a95abaa15482ad0e71e2021-12-05T12:04:42ZThe clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection10.1186/s13075-021-02675-91478-6362https://doaj.org/article/5f28c73e92f64a95abaa15482ad0e71e2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13075-021-02675-9https://doaj.org/toc/1478-6362Abstract Background Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified. Methods We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 to 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, and imaging findings were compared between patients with and without PAI. TAK was diagnosed based on the American College of Rheumatology Classification Criteria (1990) or the Japanese Clinical Diagnostic Criteria (2008). PAI was identified using enhanced computed tomography, magnetic resonance imaging, or lung scintigraphy. Results PAI was detected in 14.6% (n = 24) of total TAK patients. Dyspnea (25.0% vs. 8.6%; p = 0.043), pulmonary arterial hypertension (PAH) (16.7% vs. 0.0%; p < 0.001), ischemic heart disease (IHD) (29% vs. 9.3%; p = 0.018), respiratory infection (25.0% vs. 6.0%; p = 0.009), and nontuberculous mycobacteria (NTM) infection (20.8% vs. 0.8%; p < 0.001) were significantly more frequent, and renal artery stenosis (0% vs. 17%; p = 0.007) was significantly less frequent in TAK patients with PAI than in those without PAI. PAI and biologics were risk factors for NTM. Conclusions TAK patients with PAI more frequently have dyspnea, PAH, IHD, and respiratory infection, including NTM, than TAK patients without PAI.Hiroki MukoyamaMirei ShirakashiNozomi TanakaTakeshi IwasakiToshiki NakajimaHideo OnizawaHideaki TsujiKoji KitagoriShuji AkizukiRan NakashimaKosaku MurakamiMasao TanakaAkio MorinobuHajime YoshifujiBMCarticleTakayasu arteritisPulmonary artery involvementIschemic heart diseasesInfectionDiseases of the musculoskeletal systemRC925-935ENArthritis Research & Therapy, Vol 23, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Takayasu arteritis Pulmonary artery involvement Ischemic heart diseases Infection Diseases of the musculoskeletal system RC925-935
spellingShingle	Takayasu arteritis Pulmonary artery involvement Ischemic heart diseases Infection Diseases of the musculoskeletal system RC925-935 Hiroki Mukoyama Mirei Shirakashi Nozomi Tanaka Takeshi Iwasaki Toshiki Nakajima Hideo Onizawa Hideaki Tsuji Koji Kitagori Shuji Akizuki Ran Nakashima Kosaku Murakami Masao Tanaka Akio Morinobu Hajime Yoshifuji The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection
description	Abstract Background Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified. Methods We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 to 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, and imaging findings were compared between patients with and without PAI. TAK was diagnosed based on the American College of Rheumatology Classification Criteria (1990) or the Japanese Clinical Diagnostic Criteria (2008). PAI was identified using enhanced computed tomography, magnetic resonance imaging, or lung scintigraphy. Results PAI was detected in 14.6% (n = 24) of total TAK patients. Dyspnea (25.0% vs. 8.6%; p = 0.043), pulmonary arterial hypertension (PAH) (16.7% vs. 0.0%; p < 0.001), ischemic heart disease (IHD) (29% vs. 9.3%; p = 0.018), respiratory infection (25.0% vs. 6.0%; p = 0.009), and nontuberculous mycobacteria (NTM) infection (20.8% vs. 0.8%; p < 0.001) were significantly more frequent, and renal artery stenosis (0% vs. 17%; p = 0.007) was significantly less frequent in TAK patients with PAI than in those without PAI. PAI and biologics were risk factors for NTM. Conclusions TAK patients with PAI more frequently have dyspnea, PAH, IHD, and respiratory infection, including NTM, than TAK patients without PAI.
format	article
author	Hiroki Mukoyama Mirei Shirakashi Nozomi Tanaka Takeshi Iwasaki Toshiki Nakajima Hideo Onizawa Hideaki Tsuji Koji Kitagori Shuji Akizuki Ran Nakashima Kosaku Murakami Masao Tanaka Akio Morinobu Hajime Yoshifuji
author_facet	Hiroki Mukoyama Mirei Shirakashi Nozomi Tanaka Takeshi Iwasaki Toshiki Nakajima Hideo Onizawa Hideaki Tsuji Koji Kitagori Shuji Akizuki Ran Nakashima Kosaku Murakami Masao Tanaka Akio Morinobu Hajime Yoshifuji
author_sort	Hiroki Mukoyama
title	The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection
title_short	The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection
title_full	The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection
title_fullStr	The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection
title_full_unstemmed	The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection
title_sort	clinical features of pulmonary artery involvement in takayasu arteritis and its relationship with ischemic heart diseases and infection
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5f28c73e92f64a95abaa15482ad0e71e
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The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection

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