Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure

Abstract Evidence indicates that glucose variation (GV) plays an important role in mortality of critically ill patients. We aimed to investigate the relationship between the coefficient of variation of 24-h venous blood glucose (24-hVBGCV) and mortality among patients with acute respiratory failure....

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Autores principales:	Xiaoling Zhang, Jingjing Zhang, Jiamei Li, Ya Gao, Ruohan Li, Xuting Jin, Xiaochuang Wang, Ye Huang, Gang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f2a83a0957c49ff8cfabd328f6ccd84
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spelling	oai:doaj.org-article:5f2a83a0957c49ff8cfabd328f6ccd842021-12-02T14:26:07ZRelationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure10.1038/s41598-021-87409-22045-2322https://doaj.org/article/5f2a83a0957c49ff8cfabd328f6ccd842021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87409-2https://doaj.org/toc/2045-2322Abstract Evidence indicates that glucose variation (GV) plays an important role in mortality of critically ill patients. We aimed to investigate the relationship between the coefficient of variation of 24-h venous blood glucose (24-hVBGCV) and mortality among patients with acute respiratory failure. The records of 1625 patients in the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II) database were extracted. The 24-hVBGCV was calculated as the ratio of the standard deviation (SD) to the mean venous blood glucose level, expressed as a percentage. The outcomes included ICU mortality and in-hospital mortality. Participants were divided into three subgroups based on tertiles of 24-hVBGCV. Multivariable logistic regression models were used to evaluate the relationship between 24-hVBGCV and mortality. Sensitivity analyses were also performed in groups of patients with and without diabetes mellitus. Taking the lowest tertile as a reference, after adjustment for all the covariates, the highest tertile was significantly associated with ICU mortality [odds ratio (OR), 1.353; 95% confidence interval (CI), 1.018–1.797] and in-hospital mortality (OR, 1.319; 95% CI, 1.003–1.735), especially in the population without diabetes. The 24-hVBGCV may be associated with ICU and in-hospital mortality in patients with acute respiratory failure in the ICU, especially in those without diabetes.Xiaoling ZhangJingjing ZhangJiamei LiYa GaoRuohan LiXuting JinXiaochuang WangYe HuangGang WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoling Zhang Jingjing Zhang Jiamei Li Ya Gao Ruohan Li Xuting Jin Xiaochuang Wang Ye Huang Gang Wang Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
description	Abstract Evidence indicates that glucose variation (GV) plays an important role in mortality of critically ill patients. We aimed to investigate the relationship between the coefficient of variation of 24-h venous blood glucose (24-hVBGCV) and mortality among patients with acute respiratory failure. The records of 1625 patients in the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II) database were extracted. The 24-hVBGCV was calculated as the ratio of the standard deviation (SD) to the mean venous blood glucose level, expressed as a percentage. The outcomes included ICU mortality and in-hospital mortality. Participants were divided into three subgroups based on tertiles of 24-hVBGCV. Multivariable logistic regression models were used to evaluate the relationship between 24-hVBGCV and mortality. Sensitivity analyses were also performed in groups of patients with and without diabetes mellitus. Taking the lowest tertile as a reference, after adjustment for all the covariates, the highest tertile was significantly associated with ICU mortality [odds ratio (OR), 1.353; 95% confidence interval (CI), 1.018–1.797] and in-hospital mortality (OR, 1.319; 95% CI, 1.003–1.735), especially in the population without diabetes. The 24-hVBGCV may be associated with ICU and in-hospital mortality in patients with acute respiratory failure in the ICU, especially in those without diabetes.
format	article
author	Xiaoling Zhang Jingjing Zhang Jiamei Li Ya Gao Ruohan Li Xuting Jin Xiaochuang Wang Ye Huang Gang Wang
author_facet	Xiaoling Zhang Jingjing Zhang Jiamei Li Ya Gao Ruohan Li Xuting Jin Xiaochuang Wang Ye Huang Gang Wang
author_sort	Xiaoling Zhang
title	Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
title_short	Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
title_full	Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
title_fullStr	Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
title_full_unstemmed	Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
title_sort	relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f2a83a0957c49ff8cfabd328f6ccd84
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Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure

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