Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging.
The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome with a high risk developing multiple sclerosis were included in the study. Forty-four...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5f2ad9d6d363460ea34b7d56eca56aaf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5f2ad9d6d363460ea34b7d56eca56aaf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5f2ad9d6d363460ea34b7d56eca56aaf2021-11-04T06:08:27ZPrevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging.1932-620310.1371/journal.pone.0024969https://doaj.org/article/5f2ad9d6d363460ea34b7d56eca56aaf2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949813/?tool=EBIhttps://doaj.org/toc/1932-6203The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome with a high risk developing multiple sclerosis were included in the study. Forty-four healthy controls constituted the normative population. An optimized statistical mapping analysis was performed to compare each subject's GM Magnetization Transfer Ratio (MTR) imaging maps with those of the whole group of controls. The statistical threshold of significant GM MTR decrease was determined as the maximum p value (p<0.05 FDR) for which no significant cluster survived when comparing each control to the whole control population. Using this threshold, 51% of patients showed GM abnormalities compared to controls. Locally, 37% of patients presented abnormalities inside the limbic cortex, 34% in the temporal cortex, 32% in the deep grey matter, 30% in the cerebellum, 30% in the frontal cortex, 26% in the occipital cortex and 19% in the parietal cortex. Stepwise regression analysis evidenced significant association (p = 0.002) between EDSS and both GM pathology (p = 0.028) and T2 white matter lesions load (p = 0.019). In the present study, we evidenced that individual analysis of GM MTR map allowed demonstrating that GM pathology is highly heterogeneous across patients at the early stage of MS and partly underlies irreversible disability.Lydie CrespyWafaa ZaaraouiMathias LemaireAudrey RicoAnthony FaivreFrançoise ReuterIrina MalikovaSylviane Confort-GounyPatrick J CozzoneJean PelletierJean-Philippe RanjevaBertrand AudoinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24969 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Lydie Crespy Wafaa Zaaraoui Mathias Lemaire Audrey Rico Anthony Faivre Françoise Reuter Irina Malikova Sylviane Confort-Gouny Patrick J Cozzone Jean Pelletier Jean-Philippe Ranjeva Bertrand Audoin Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| description |
The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome with a high risk developing multiple sclerosis were included in the study. Forty-four healthy controls constituted the normative population. An optimized statistical mapping analysis was performed to compare each subject's GM Magnetization Transfer Ratio (MTR) imaging maps with those of the whole group of controls. The statistical threshold of significant GM MTR decrease was determined as the maximum p value (p<0.05 FDR) for which no significant cluster survived when comparing each control to the whole control population. Using this threshold, 51% of patients showed GM abnormalities compared to controls. Locally, 37% of patients presented abnormalities inside the limbic cortex, 34% in the temporal cortex, 32% in the deep grey matter, 30% in the cerebellum, 30% in the frontal cortex, 26% in the occipital cortex and 19% in the parietal cortex. Stepwise regression analysis evidenced significant association (p = 0.002) between EDSS and both GM pathology (p = 0.028) and T2 white matter lesions load (p = 0.019). In the present study, we evidenced that individual analysis of GM MTR map allowed demonstrating that GM pathology is highly heterogeneous across patients at the early stage of MS and partly underlies irreversible disability. |
| format |
article |
| author |
Lydie Crespy Wafaa Zaaraoui Mathias Lemaire Audrey Rico Anthony Faivre Françoise Reuter Irina Malikova Sylviane Confort-Gouny Patrick J Cozzone Jean Pelletier Jean-Philippe Ranjeva Bertrand Audoin |
| author_facet |
Lydie Crespy Wafaa Zaaraoui Mathias Lemaire Audrey Rico Anthony Faivre Françoise Reuter Irina Malikova Sylviane Confort-Gouny Patrick J Cozzone Jean Pelletier Jean-Philippe Ranjeva Bertrand Audoin |
| author_sort |
Lydie Crespy |
| title |
Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| title_short |
Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| title_full |
Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| title_fullStr |
Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| title_full_unstemmed |
Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| title_sort |
prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/5f2ad9d6d363460ea34b7d56eca56aaf |
| work_keys_str_mv |
AT lydiecrespy prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT wafaazaaraoui prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT mathiaslemaire prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT audreyrico prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT anthonyfaivre prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT francoisereuter prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT irinamalikova prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT sylvianeconfortgouny prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT patrickjcozzone prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT jeanpelletier prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT jeanphilipperanjeva prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging AT bertrandaudoin prevalenceofgreymatterpathologyinearlymultiplesclerosisassessedbymagnetizationtransferratioimaging |
| _version_ |
1718445151344394240 |