Homeostatic regulation of STING by retrograde membrane traffic to the ER

Homeostatic regulation of STING by retrograde membrane traffic to the ER

COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.

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Bibliographic Details
Main Authors: Kojiro Mukai, Emari Ogawa, Rei Uematsu, Yoshihiko Kuchitsu, Fumika Kiku, Takefumi Uemura, Satoshi Waguri, Takehiro Suzuki, Naoshi Dohmae, Hiroyuki Arai, Anthony K. Shum, Tomohiko Taguchi
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/5f2b94b366d546d681b2cdd4058de2b2
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Summary:COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.

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