Homeostatic regulation of STING by retrograde membrane traffic to the ER

COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.

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Autores principales:	Kojiro Mukai, Emari Ogawa, Rei Uematsu, Yoshihiko Kuchitsu, Fumika Kiku, Takefumi Uemura, Satoshi Waguri, Takehiro Suzuki, Naoshi Dohmae, Hiroyuki Arai, Anthony K. Shum, Tomohiko Taguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f2b94b366d546d681b2cdd4058de2b2
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spelling	oai:doaj.org-article:5f2b94b366d546d681b2cdd4058de2b22021-12-02T15:08:00ZHomeostatic regulation of STING by retrograde membrane traffic to the ER10.1038/s41467-020-20234-92041-1723https://doaj.org/article/5f2b94b366d546d681b2cdd4058de2b22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20234-9https://doaj.org/toc/2041-1723COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.Kojiro MukaiEmari OgawaRei UematsuYoshihiko KuchitsuFumika KikuTakefumi UemuraSatoshi WaguriTakehiro SuzukiNaoshi DohmaeHiroyuki AraiAnthony K. ShumTomohiko TaguchiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kojiro Mukai Emari Ogawa Rei Uematsu Yoshihiko Kuchitsu Fumika Kiku Takefumi Uemura Satoshi Waguri Takehiro Suzuki Naoshi Dohmae Hiroyuki Arai Anthony K. Shum Tomohiko Taguchi Homeostatic regulation of STING by retrograde membrane traffic to the ER
description	COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.
format	article
author	Kojiro Mukai Emari Ogawa Rei Uematsu Yoshihiko Kuchitsu Fumika Kiku Takefumi Uemura Satoshi Waguri Takehiro Suzuki Naoshi Dohmae Hiroyuki Arai Anthony K. Shum Tomohiko Taguchi
author_facet	Kojiro Mukai Emari Ogawa Rei Uematsu Yoshihiko Kuchitsu Fumika Kiku Takefumi Uemura Satoshi Waguri Takehiro Suzuki Naoshi Dohmae Hiroyuki Arai Anthony K. Shum Tomohiko Taguchi
author_sort	Kojiro Mukai
title	Homeostatic regulation of STING by retrograde membrane traffic to the ER
title_short	Homeostatic regulation of STING by retrograde membrane traffic to the ER
title_full	Homeostatic regulation of STING by retrograde membrane traffic to the ER
title_fullStr	Homeostatic regulation of STING by retrograde membrane traffic to the ER
title_full_unstemmed	Homeostatic regulation of STING by retrograde membrane traffic to the ER
title_sort	homeostatic regulation of sting by retrograde membrane traffic to the er
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f2b94b366d546d681b2cdd4058de2b2
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Homeostatic regulation of STING by retrograde membrane traffic to the ER

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