Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.
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Nature Portfolio
2020
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oai:doaj.org-article:5f2bea014f994236b4d2abd38b628f2e2021-12-02T18:49:29ZSingle-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination10.1038/s41467-020-17740-12041-1723https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17740-1https://doaj.org/toc/2041-1723To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.Lars MuhlGuillem GenovéStefanos LeptidisJianping LiuLiqun HeGiuseppe MocciYing SunSonja GustafssonByambajav BuyandelgerIndira V. ChivukulaÅsa SegerstolpeElisabeth RaschpergerEmil M. HanssonJohan L. M. BjörkegrenXiao-Rong PengMichael VanlandewijckUrban LendahlChrister BetsholtzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
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Science Q |
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Science Q Lars Muhl Guillem Genové Stefanos Leptidis Jianping Liu Liqun He Giuseppe Mocci Ying Sun Sonja Gustafsson Byambajav Buyandelger Indira V. Chivukula Åsa Segerstolpe Elisabeth Raschperger Emil M. Hansson Johan L. M. Björkegren Xiao-Rong Peng Michael Vanlandewijck Urban Lendahl Christer Betsholtz Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
description |
To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types. |
format |
article |
author |
Lars Muhl Guillem Genové Stefanos Leptidis Jianping Liu Liqun He Giuseppe Mocci Ying Sun Sonja Gustafsson Byambajav Buyandelger Indira V. Chivukula Åsa Segerstolpe Elisabeth Raschperger Emil M. Hansson Johan L. M. Björkegren Xiao-Rong Peng Michael Vanlandewijck Urban Lendahl Christer Betsholtz |
author_facet |
Lars Muhl Guillem Genové Stefanos Leptidis Jianping Liu Liqun He Giuseppe Mocci Ying Sun Sonja Gustafsson Byambajav Buyandelger Indira V. Chivukula Åsa Segerstolpe Elisabeth Raschperger Emil M. Hansson Johan L. M. Björkegren Xiao-Rong Peng Michael Vanlandewijck Urban Lendahl Christer Betsholtz |
author_sort |
Lars Muhl |
title |
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
title_short |
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
title_full |
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
title_fullStr |
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
title_full_unstemmed |
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
title_sort |
single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e |
work_keys_str_mv |
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