Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.

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Autores principales: Lars Muhl, Guillem Genové, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira V. Chivukula, Åsa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Björkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e
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spelling oai:doaj.org-article:5f2bea014f994236b4d2abd38b628f2e2021-12-02T18:49:29ZSingle-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination10.1038/s41467-020-17740-12041-1723https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17740-1https://doaj.org/toc/2041-1723To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.Lars MuhlGuillem GenovéStefanos LeptidisJianping LiuLiqun HeGiuseppe MocciYing SunSonja GustafssonByambajav BuyandelgerIndira V. ChivukulaÅsa SegerstolpeElisabeth RaschpergerEmil M. HanssonJohan L. M. BjörkegrenXiao-Rong PengMichael VanlandewijckUrban LendahlChrister BetsholtzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lars Muhl
Guillem Genové
Stefanos Leptidis
Jianping Liu
Liqun He
Giuseppe Mocci
Ying Sun
Sonja Gustafsson
Byambajav Buyandelger
Indira V. Chivukula
Åsa Segerstolpe
Elisabeth Raschperger
Emil M. Hansson
Johan L. M. Björkegren
Xiao-Rong Peng
Michael Vanlandewijck
Urban Lendahl
Christer Betsholtz
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
description To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.
format article
author Lars Muhl
Guillem Genové
Stefanos Leptidis
Jianping Liu
Liqun He
Giuseppe Mocci
Ying Sun
Sonja Gustafsson
Byambajav Buyandelger
Indira V. Chivukula
Åsa Segerstolpe
Elisabeth Raschperger
Emil M. Hansson
Johan L. M. Björkegren
Xiao-Rong Peng
Michael Vanlandewijck
Urban Lendahl
Christer Betsholtz
author_facet Lars Muhl
Guillem Genové
Stefanos Leptidis
Jianping Liu
Liqun He
Giuseppe Mocci
Ying Sun
Sonja Gustafsson
Byambajav Buyandelger
Indira V. Chivukula
Åsa Segerstolpe
Elisabeth Raschperger
Emil M. Hansson
Johan L. M. Björkegren
Xiao-Rong Peng
Michael Vanlandewijck
Urban Lendahl
Christer Betsholtz
author_sort Lars Muhl
title Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
title_short Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
title_full Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
title_fullStr Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
title_full_unstemmed Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
title_sort single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e
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