Genetic and epigenetic basis of hepatoblastoma diversity

While hepatoblastoma is the most common pediatric liver cancer, its molecular background has not been fully characterised. Here, the authors perform genomic and epigenomic profiling of 163 untreated pediatric liver tumours and suggest the upregulation of ASCL2 and methylation patterns of IGF2 promot...

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Autores principales:	Genta Nagae, Shogo Yamamoto, Masashi Fujita, Takanori Fujita, Aya Nonaka, Takayoshi Umeda, Shiro Fukuda, Kenji Tatsuno, Kazuhiro Maejima, Akimasa Hayashi, Sho Kurihara, Masato Kojima, Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Michihiro Yano, Yoko Hiyama, Yukichi Tanaka, Takeshi Inoue, Hiroki Ueda, Hidewaki Nakagawa, Hiroyuki Aburatani, Eiso Hiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f3064223f474f6c908aa9492d92dd6b
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spelling	oai:doaj.org-article:5f3064223f474f6c908aa9492d92dd6b2021-12-02T15:14:56ZGenetic and epigenetic basis of hepatoblastoma diversity10.1038/s41467-021-25430-92041-1723https://doaj.org/article/5f3064223f474f6c908aa9492d92dd6b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25430-9https://doaj.org/toc/2041-1723While hepatoblastoma is the most common pediatric liver cancer, its molecular background has not been fully characterised. Here, the authors perform genomic and epigenomic profiling of 163 untreated pediatric liver tumours and suggest the upregulation of ASCL2 and methylation patterns of IGF2 promoters in driving hepatoblast carcinogenesis.Genta NagaeShogo YamamotoMasashi FujitaTakanori FujitaAya NonakaTakayoshi UmedaShiro FukudaKenji TatsunoKazuhiro MaejimaAkimasa HayashiSho KuriharaMasato KojimaTomoro HishikiKenichiro WatanabeKohmei IdaMichihiro YanoYoko HiyamaYukichi TanakaTakeshi InoueHiroki UedaHidewaki NakagawaHiroyuki AburataniEiso HiyamaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Genta Nagae Shogo Yamamoto Masashi Fujita Takanori Fujita Aya Nonaka Takayoshi Umeda Shiro Fukuda Kenji Tatsuno Kazuhiro Maejima Akimasa Hayashi Sho Kurihara Masato Kojima Tomoro Hishiki Kenichiro Watanabe Kohmei Ida Michihiro Yano Yoko Hiyama Yukichi Tanaka Takeshi Inoue Hiroki Ueda Hidewaki Nakagawa Hiroyuki Aburatani Eiso Hiyama Genetic and epigenetic basis of hepatoblastoma diversity
description	While hepatoblastoma is the most common pediatric liver cancer, its molecular background has not been fully characterised. Here, the authors perform genomic and epigenomic profiling of 163 untreated pediatric liver tumours and suggest the upregulation of ASCL2 and methylation patterns of IGF2 promoters in driving hepatoblast carcinogenesis.
format	article
author	Genta Nagae Shogo Yamamoto Masashi Fujita Takanori Fujita Aya Nonaka Takayoshi Umeda Shiro Fukuda Kenji Tatsuno Kazuhiro Maejima Akimasa Hayashi Sho Kurihara Masato Kojima Tomoro Hishiki Kenichiro Watanabe Kohmei Ida Michihiro Yano Yoko Hiyama Yukichi Tanaka Takeshi Inoue Hiroki Ueda Hidewaki Nakagawa Hiroyuki Aburatani Eiso Hiyama
author_facet	Genta Nagae Shogo Yamamoto Masashi Fujita Takanori Fujita Aya Nonaka Takayoshi Umeda Shiro Fukuda Kenji Tatsuno Kazuhiro Maejima Akimasa Hayashi Sho Kurihara Masato Kojima Tomoro Hishiki Kenichiro Watanabe Kohmei Ida Michihiro Yano Yoko Hiyama Yukichi Tanaka Takeshi Inoue Hiroki Ueda Hidewaki Nakagawa Hiroyuki Aburatani Eiso Hiyama
author_sort	Genta Nagae
title	Genetic and epigenetic basis of hepatoblastoma diversity
title_short	Genetic and epigenetic basis of hepatoblastoma diversity
title_full	Genetic and epigenetic basis of hepatoblastoma diversity
title_fullStr	Genetic and epigenetic basis of hepatoblastoma diversity
title_full_unstemmed	Genetic and epigenetic basis of hepatoblastoma diversity
title_sort	genetic and epigenetic basis of hepatoblastoma diversity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f3064223f474f6c908aa9492d92dd6b
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Genetic and epigenetic basis of hepatoblastoma diversity

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