Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux

BACKGROUND AND OBJECTIVE: Primary vesicoureteral reflux (VUR) is a hereditary disease and the risk of scar increased with VUR. In a few years ago, probability of renal scar formation before delivery and urinary tract infection is suggested. So, this study was done to evaluate this theory and detecti...

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Autores principales:	H Sorkhi, M Mojtabaei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	neonates prenatal hydronephrosis vesicoureteral reflux renal scar Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5f3066cc5fe04255abeb5695ca37a1ce
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spelling	oai:doaj.org-article:5f3066cc5fe04255abeb5695ca37a1ce2021-11-10T08:53:02ZRenal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux1561-41072251-7170https://doaj.org/article/5f3066cc5fe04255abeb5695ca37a1ce2012-03-01T00:00:00Zhttp://jbums.org/article-1-4046-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Primary vesicoureteral reflux (VUR) is a hereditary disease and the risk of scar increased with VUR. In a few years ago, probability of renal scar formation before delivery and urinary tract infection is suggested. So, this study was done to evaluate this theory and detection of renal scar in neonates with prenatal hydronephrosis and VUR.METHODS: This cross sectional study was performed on 59 neonates with history of prenatal hydronephrosis. The hydronephrosis were proved after delivery and VCUG (voiding cystourethrography) was done with negative urine cultures. For detection of scar (decrease radioisotope absorption), DMSA (Dimercaptosuccinic Acid) was done in all neonates with VUR. Scar in grade I-V was assessed.FINDINGS: This study was done in 59 neonates with history of prenatal hydronephrosis and VUR. Thirty nine (66.1%) neonates were boy and others were girl. Among 116 kidney units, 95 units had VUR and 51 (53.7%) units had scar. Thirsty nine (62%) units with VUR in boys and 12 (37.5%) units in girls had scar (p<0.05). Also, none of units with grade I had scar. Scar in grade II-V was 37.5%, 42.1%, 48.1% and 88.5%, respectively (p<0.05).CONCLUSION: The existence of high rate scar in these neonates, especially in males and with high grade VUR indicated that early diagnosis and also prevention of UTI and new scare formation is very important.H SorkhiM MojtabaeiBabol University of Medical Sciencesarticleneonatesprenatal hydronephrosisvesicoureteral refluxrenal scarMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 2, Pp 53-58 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	neonates prenatal hydronephrosis vesicoureteral reflux renal scar Medicine R Medicine (General) R5-920
spellingShingle	neonates prenatal hydronephrosis vesicoureteral reflux renal scar Medicine R Medicine (General) R5-920 H Sorkhi M Mojtabaei Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux
description	BACKGROUND AND OBJECTIVE: Primary vesicoureteral reflux (VUR) is a hereditary disease and the risk of scar increased with VUR. In a few years ago, probability of renal scar formation before delivery and urinary tract infection is suggested. So, this study was done to evaluate this theory and detection of renal scar in neonates with prenatal hydronephrosis and VUR.METHODS: This cross sectional study was performed on 59 neonates with history of prenatal hydronephrosis. The hydronephrosis were proved after delivery and VCUG (voiding cystourethrography) was done with negative urine cultures. For detection of scar (decrease radioisotope absorption), DMSA (Dimercaptosuccinic Acid) was done in all neonates with VUR. Scar in grade I-V was assessed.FINDINGS: This study was done in 59 neonates with history of prenatal hydronephrosis and VUR. Thirty nine (66.1%) neonates were boy and others were girl. Among 116 kidney units, 95 units had VUR and 51 (53.7%) units had scar. Thirsty nine (62%) units with VUR in boys and 12 (37.5%) units in girls had scar (p<0.05). Also, none of units with grade I had scar. Scar in grade II-V was 37.5%, 42.1%, 48.1% and 88.5%, respectively (p<0.05).CONCLUSION: The existence of high rate scar in these neonates, especially in males and with high grade VUR indicated that early diagnosis and also prevention of UTI and new scare formation is very important.
format	article
author	H Sorkhi M Mojtabaei
author_facet	H Sorkhi M Mojtabaei
author_sort	H Sorkhi
title	Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux
title_short	Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux
title_full	Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux
title_fullStr	Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux
title_full_unstemmed	Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux
title_sort	renal scaring in infants with prenatal hydronephrosis and vesicoureteral reflux
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/5f3066cc5fe04255abeb5695ca37a1ce
work_keys_str_mv	AT hsorkhi renalscaringininfantswithprenatalhydronephrosisandvesicoureteralreflux AT mmojtabaei renalscaringininfantswithprenatalhydronephrosisandvesicoureteralreflux
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Renal Scaring in Infants with Prenatal Hydronephrosis and Vesicoureteral Reflux

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