Inhibition of post-transcriptional steps in ribosome biogenesis confers cytoprotection against chemotherapeutic agents in a p53-dependent manner

Abstract The p53-mediated nucleolar stress response associated with inhibition of ribosomal RNA transcription was previously shown to potentiate killing of tumor cells. Here, we asked whether targeting of ribosome biogenesis can be used as the basis for selective p53-dependent cytoprotection of nonm...

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Autores principales: Russell T. Sapio, Anastasiya N. Nezdyur, Matthew Krevetski, Leonid Anikin, Vincent J. Manna, Natalie Minkovsky, Dimitri G. Pestov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5f32b7cad4d346218524d5760ba81655
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