PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS

Antiviral research has focused mainly on viral targets. However, cellular targets involved in the viral life cycle and antiviral response are becoming more attractive for research, providing a variety of opportunities for antiviral therapy. Toll-like receptors (TLR) play an important role in activat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. A. Nikonova, M. R. Khaitov, R. M. Khaitov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	tlr agonists antagonists respiratory viral infections Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5f386ea5083c42cda219ff3bd99499be
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5f386ea5083c42cda219ff3bd99499be
record_format	dspace
spelling	oai:doaj.org-article:5f386ea5083c42cda219ff3bd99499be2021-11-18T08:03:48ZPROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS1563-06252313-741X10.15789/1563-0625-2019-3-397-406https://doaj.org/article/5f386ea5083c42cda219ff3bd99499be2019-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1813https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAntiviral research has focused mainly on viral targets. However, cellular targets involved in the viral life cycle and antiviral response are becoming more attractive for research, providing a variety of opportunities for antiviral therapy. Toll-like receptors (TLR) play an important role in activation of both innate and adaptive immune systems, including a response to respiratory viral infections. In this review we shall discuss TLRs as potential targets for development of novel antiviral drugs including the mechanisms for induction the antiviral response by means of type I interferon production, as well as viral evasion strategies. In addition, we describe several new molecules that have been applied as TLR agonists or antagonists. The safety issues are also discussed.A. A. NikonovaM. R. KhaitovR. M. KhaitovSPb RAACIarticletlragonistsantagonistsrespiratory viral infectionsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 3, Pp 397-406 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	tlr agonists antagonists respiratory viral infections Immunologic diseases. Allergy RC581-607
spellingShingle	tlr agonists antagonists respiratory viral infections Immunologic diseases. Allergy RC581-607 A. A. Nikonova M. R. Khaitov R. M. Khaitov PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
description	Antiviral research has focused mainly on viral targets. However, cellular targets involved in the viral life cycle and antiviral response are becoming more attractive for research, providing a variety of opportunities for antiviral therapy. Toll-like receptors (TLR) play an important role in activation of both innate and adaptive immune systems, including a response to respiratory viral infections. In this review we shall discuss TLRs as potential targets for development of novel antiviral drugs including the mechanisms for induction the antiviral response by means of type I interferon production, as well as viral evasion strategies. In addition, we describe several new molecules that have been applied as TLR agonists or antagonists. The safety issues are also discussed.
format	article
author	A. A. Nikonova M. R. Khaitov R. M. Khaitov
author_facet	A. A. Nikonova M. R. Khaitov R. M. Khaitov
author_sort	A. A. Nikonova
title	PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
title_short	PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
title_full	PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
title_fullStr	PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
title_full_unstemmed	PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
title_sort	prospects of toll-like receptor agonists and antagonists for prevention and treatment of viral infections
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/5f386ea5083c42cda219ff3bd99499be
work_keys_str_mv	AT aanikonova prospectsoftolllikereceptoragonistsandantagonistsforpreventionandtreatmentofviralinfections AT mrkhaitov prospectsoftolllikereceptoragonistsandantagonistsforpreventionandtreatmentofviralinfections AT rmkhaitov prospectsoftolllikereceptoragonistsandantagonistsforpreventionandtreatmentofviralinfections
_version_	1718422351414034432

PROSPECTS OF Toll-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS

Ejemplares similares