Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

Nanoparticles are being explored as a potential method to target Aβ aggregation in Alzheimer’s disease. Here, the authors develop gold nanoparticles that were capped with chiral L or D-glutathione which has been shown to improve BBB permeability and demonstrate their ability to improve cognitive fun...

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Autores principales:	Ke Hou, Jing Zhao, Hui Wang, Bin Li, Kexin Li, Xinghua Shi, Kaiwei Wan, Jing Ai, Jiawei Lv, Dawei Wang, Qunxing Huang, Huayi Wang, Qin Cao, Shaoqin Liu, Zhiyong Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f3b317f18a94dfbb108df54eea815d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5f3b317f18a94dfbb108df54eea815d32021-12-02T17:26:56ZChiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease10.1038/s41467-020-18525-22041-1723https://doaj.org/article/5f3b317f18a94dfbb108df54eea815d32020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18525-2https://doaj.org/toc/2041-1723Nanoparticles are being explored as a potential method to target Aβ aggregation in Alzheimer’s disease. Here, the authors develop gold nanoparticles that were capped with chiral L or D-glutathione which has been shown to improve BBB permeability and demonstrate their ability to improve cognitive function in a mouse model of AD.Ke HouJing ZhaoHui WangBin LiKexin LiXinghua ShiKaiwei WanJing AiJiawei LvDawei WangQunxing HuangHuayi WangQin CaoShaoqin LiuZhiyong TangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ke Hou Jing Zhao Hui Wang Bin Li Kexin Li Xinghua Shi Kaiwei Wan Jing Ai Jiawei Lv Dawei Wang Qunxing Huang Huayi Wang Qin Cao Shaoqin Liu Zhiyong Tang Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
description	Nanoparticles are being explored as a potential method to target Aβ aggregation in Alzheimer’s disease. Here, the authors develop gold nanoparticles that were capped with chiral L or D-glutathione which has been shown to improve BBB permeability and demonstrate their ability to improve cognitive function in a mouse model of AD.
format	article
author	Ke Hou Jing Zhao Hui Wang Bin Li Kexin Li Xinghua Shi Kaiwei Wan Jing Ai Jiawei Lv Dawei Wang Qunxing Huang Huayi Wang Qin Cao Shaoqin Liu Zhiyong Tang
author_facet	Ke Hou Jing Zhao Hui Wang Bin Li Kexin Li Xinghua Shi Kaiwei Wan Jing Ai Jiawei Lv Dawei Wang Qunxing Huang Huayi Wang Qin Cao Shaoqin Liu Zhiyong Tang
author_sort	Ke Hou
title	Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
title_short	Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
title_full	Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
title_fullStr	Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
title_full_unstemmed	Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
title_sort	chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f3b317f18a94dfbb108df54eea815d3
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Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

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