Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain

Neural precursors originating in the subventricular zone (SVZ), the largest neurogenic region of the adult brain, migrate several millimeters along a restricted migratory pathway, the rostral migratory stream (RMS), toward the olfactory bulb (OB), where they differentiate into interneurons and integ...

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Autores principales:	Marcela Martončíková, Anna Alexovič Matiašová, Juraj Ševc, Enikő Račeková
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	blood vessels neuroblast migration rostral migratory stream adult neurogenesis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5f3e890d169747629c9b5c9f7a6280ae
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spelling	oai:doaj.org-article:5f3e890d169747629c9b5c9f7a6280ae2021-11-11T16:58:04ZRelationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain10.3390/ijms2221115061422-00671661-6596https://doaj.org/article/5f3e890d169747629c9b5c9f7a6280ae2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11506https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Neural precursors originating in the subventricular zone (SVZ), the largest neurogenic region of the adult brain, migrate several millimeters along a restricted migratory pathway, the rostral migratory stream (RMS), toward the olfactory bulb (OB), where they differentiate into interneurons and integrate into the local neuronal circuits. Migration of SVZ-derived neuroblasts in the adult brain differs in many aspects from that in the embryonic period. Unlike in that period, postnatally-generated neuroblasts in the SVZ are able to divide during migration along the RMS, as well as they migrate independently of radial glia. The homophilic mode of migration, i.e., using each other to move, is typical for neuroblast movement in the RMS. In addition, it has recently been demonstrated that specifically-arranged blood vessels navigate SVZ-derived neuroblasts to the OB and provide signals which promote migration. Here we review the development of vasculature in the presumptive neurogenic region of the rodent brain during the embryonic period as well as the development of the vascular scaffold guiding neuroblast migration in the postnatal period, and the significance of blood vessel reorganization during the early postnatal period for proper migration of RMS neuroblasts in adulthood.Marcela MartončíkováAnna Alexovič MatiašováJuraj ŠevcEnikő RačekováMDPI AGarticleblood vesselsneuroblast migrationrostral migratory streamadult neurogenesisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11506, p 11506 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood vessels neuroblast migration rostral migratory stream adult neurogenesis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	blood vessels neuroblast migration rostral migratory stream adult neurogenesis Biology (General) QH301-705.5 Chemistry QD1-999 Marcela Martončíková Anna Alexovič Matiašová Juraj Ševc Enikő Račeková Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain
description	Neural precursors originating in the subventricular zone (SVZ), the largest neurogenic region of the adult brain, migrate several millimeters along a restricted migratory pathway, the rostral migratory stream (RMS), toward the olfactory bulb (OB), where they differentiate into interneurons and integrate into the local neuronal circuits. Migration of SVZ-derived neuroblasts in the adult brain differs in many aspects from that in the embryonic period. Unlike in that period, postnatally-generated neuroblasts in the SVZ are able to divide during migration along the RMS, as well as they migrate independently of radial glia. The homophilic mode of migration, i.e., using each other to move, is typical for neuroblast movement in the RMS. In addition, it has recently been demonstrated that specifically-arranged blood vessels navigate SVZ-derived neuroblasts to the OB and provide signals which promote migration. Here we review the development of vasculature in the presumptive neurogenic region of the rodent brain during the embryonic period as well as the development of the vascular scaffold guiding neuroblast migration in the postnatal period, and the significance of blood vessel reorganization during the early postnatal period for proper migration of RMS neuroblasts in adulthood.
format	article
author	Marcela Martončíková Anna Alexovič Matiašová Juraj Ševc Enikő Račeková
author_facet	Marcela Martončíková Anna Alexovič Matiašová Juraj Ševc Enikő Račeková
author_sort	Marcela Martončíková
title	Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain
title_short	Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain
title_full	Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain
title_fullStr	Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain
title_full_unstemmed	Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain
title_sort	relationship between blood vessels and migration of neuroblasts in the olfactory neurogenic region of the rodent brain
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5f3e890d169747629c9b5c9f7a6280ae
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Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain

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