Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent

Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first descriptio...

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Autores principales:	Carla Bellomo, Daniel Oscar Alonso, Tamara Ricardo, Rocío Coelho, Sebastián Kehl, Natalia Periolo, Viviana Azogaray, Natalia Casas, Mariano Ottonelli, Laura Cristina Bergero, María Carolina Cudós, María Andrea Previtali, Valeria Paula Martinez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/5f3fab23f8f1415a8907912808cafd82
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spelling	oai:doaj.org-article:5f3fab23f8f1415a8907912808cafd822021-11-25T06:33:06ZEmerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent1935-27271935-2735https://doaj.org/article/5f3fab23f8f1415a8907912808cafd822021-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598061/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported in Argentina. Until now, Alto Paraguay virus was considered a non-pathogenic orthohantavirus since it was identified in a rodent, Holochilus chacarius. In addition to this, with the goal of identifying potential hantavirus host species in the province of Santa Fe, we finally describe a novel orthohantavirus found in the native rodent Scapteromys aquaticus, which differed from other hantaviruses described in the country so far. Our findings implicate an epidemiological warning regarding these new orthohantaviruses circulating in Central Argentina as well as new rodent species that must be considered as hosts from now on. Author summary The term Hantavirus groups viruses that can cause human diseases and also viruses considered non-pathogenic. An increasing number of rodents, bats, shrew and moles have been identified as hantavirus reservoirs. Hantavirus pulmonary syndrome (HPS) is a severe disease caused by some of these viruses transmitted by rodent species. HPS is considered an emerging disease due to the enormous diversity of reservoirs that have been identified, which implicate new geographical areas affected and novel potential transmission routes. Their high fatality rates make it a serious public health concern. In the COVID-19 pandemic context, we described an HPS case in Central Argentina but outside the known endemic area. The infecting hantavirus characterized was Alto Paraguay virus, considered non-pathogenic to date. In order to identify the reservoir implicated, a study was carried out in available rodent samples from a nearby area. Although we were not able to find its reservoir, unexpectedly, a new hantavirus was identified: Leyes orthohantavirus. Additionally, a new reservoir was also identified, Scapteromys aquaticus. Our findings implicate an epidemiological warning regarding these new hantaviruses circulating in Central Argentina. There are no vaccines or specific treatments for HPS, therefore prevention actions are a key to reduce the impact of this disease.Carla BellomoDaniel Oscar AlonsoTamara RicardoRocío CoelhoSebastián KehlNatalia PerioloViviana AzogarayNatalia CasasMariano OttonelliLaura Cristina BergeroMaría Carolina CudósMaría Andrea PrevitaliValeria Paula MartinezPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Carla Bellomo Daniel Oscar Alonso Tamara Ricardo Rocío Coelho Sebastián Kehl Natalia Periolo Viviana Azogaray Natalia Casas Mariano Ottonelli Laura Cristina Bergero María Carolina Cudós María Andrea Previtali Valeria Paula Martinez Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
description	Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported in Argentina. Until now, Alto Paraguay virus was considered a non-pathogenic orthohantavirus since it was identified in a rodent, Holochilus chacarius. In addition to this, with the goal of identifying potential hantavirus host species in the province of Santa Fe, we finally describe a novel orthohantavirus found in the native rodent Scapteromys aquaticus, which differed from other hantaviruses described in the country so far. Our findings implicate an epidemiological warning regarding these new orthohantaviruses circulating in Central Argentina as well as new rodent species that must be considered as hosts from now on. Author summary The term Hantavirus groups viruses that can cause human diseases and also viruses considered non-pathogenic. An increasing number of rodents, bats, shrew and moles have been identified as hantavirus reservoirs. Hantavirus pulmonary syndrome (HPS) is a severe disease caused by some of these viruses transmitted by rodent species. HPS is considered an emerging disease due to the enormous diversity of reservoirs that have been identified, which implicate new geographical areas affected and novel potential transmission routes. Their high fatality rates make it a serious public health concern. In the COVID-19 pandemic context, we described an HPS case in Central Argentina but outside the known endemic area. The infecting hantavirus characterized was Alto Paraguay virus, considered non-pathogenic to date. In order to identify the reservoir implicated, a study was carried out in available rodent samples from a nearby area. Although we were not able to find its reservoir, unexpectedly, a new hantavirus was identified: Leyes orthohantavirus. Additionally, a new reservoir was also identified, Scapteromys aquaticus. Our findings implicate an epidemiological warning regarding these new hantaviruses circulating in Central Argentina. There are no vaccines or specific treatments for HPS, therefore prevention actions are a key to reduce the impact of this disease.
format	article
author	Carla Bellomo Daniel Oscar Alonso Tamara Ricardo Rocío Coelho Sebastián Kehl Natalia Periolo Viviana Azogaray Natalia Casas Mariano Ottonelli Laura Cristina Bergero María Carolina Cudós María Andrea Previtali Valeria Paula Martinez
author_facet	Carla Bellomo Daniel Oscar Alonso Tamara Ricardo Rocío Coelho Sebastián Kehl Natalia Periolo Viviana Azogaray Natalia Casas Mariano Ottonelli Laura Cristina Bergero María Carolina Cudós María Andrea Previtali Valeria Paula Martinez
author_sort	Carla Bellomo
title	Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_short	Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_full	Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_fullStr	Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_full_unstemmed	Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_sort	emerging hantaviruses in central argentina: first case of hantavirus pulmonary syndrome caused by alto paraguay virus, and a novel orthohantavirus in scapteromys aquaticus rodent
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5f3fab23f8f1415a8907912808cafd82
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Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent

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