Maedi-Visna virus: current perspectives

Esperanza Gomez-Lucia, Nuria Barquero, Ana Domenech Department of Animal Health, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain Abstract: Maedi-Visna virus (MVV) and caprine arthritis-encephalitis virus are commonly known as small ruminant lentiviruses (SRLVs) due to their gen...

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Autores principales:	Gomez-Lucia E, Barquero N, Domenech A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Small ruminant lentivirus molecular biology immune response genetic resistance Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/5f4236a0af754fc6a14243742f5d407f
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spelling	oai:doaj.org-article:5f4236a0af754fc6a14243742f5d407f2021-12-02T05:30:06ZMaedi-Visna virus: current perspectives2230-2034https://doaj.org/article/5f4236a0af754fc6a14243742f5d407f2018-05-01T00:00:00Zhttps://www.dovepress.com/maedi-visna-virus-current-perspectives-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Esperanza Gomez-Lucia, Nuria Barquero, Ana Domenech Department of Animal Health, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain Abstract: Maedi-Visna virus (MVV) and caprine arthritis-encephalitis virus are commonly known as small ruminant lentiviruses (SRLVs) due to their genetic, structural, and pathogenic similarities. They produce lifelong lasting infections in their hosts, which are characterized by slow progression till overt disease happens. There are four major clinical forms derived from a chronic inflammatory response due to the constant low grade production of viruses from monocyte-derived macrophages: respiratory (caused by interstitial pneumonia), mammary (which may produce a decrease in milk production due to subclinical mastitis), joint (characterized by lameness), and neurological (characterized by chronic nonpurulent meningoencephalomyelitis). There are three levels which try to eliminate the virus: cellular, body, and the flock level. However, SRLVs have ways to counteract these defenses. This review examines some of them. Keywords: small ruminant lentivirus, molecular biology, immune response, genetic resistanceGomez-Lucia EBarquero NDomenech ADove Medical PressarticleSmall ruminant lentivirusmolecular biologyimmune responsegenetic resistanceVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 9, Pp 11-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Small ruminant lentivirus molecular biology immune response genetic resistance Veterinary medicine SF600-1100
spellingShingle	Small ruminant lentivirus molecular biology immune response genetic resistance Veterinary medicine SF600-1100 Gomez-Lucia E Barquero N Domenech A Maedi-Visna virus: current perspectives
description	Esperanza Gomez-Lucia, Nuria Barquero, Ana Domenech Department of Animal Health, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain Abstract: Maedi-Visna virus (MVV) and caprine arthritis-encephalitis virus are commonly known as small ruminant lentiviruses (SRLVs) due to their genetic, structural, and pathogenic similarities. They produce lifelong lasting infections in their hosts, which are characterized by slow progression till overt disease happens. There are four major clinical forms derived from a chronic inflammatory response due to the constant low grade production of viruses from monocyte-derived macrophages: respiratory (caused by interstitial pneumonia), mammary (which may produce a decrease in milk production due to subclinical mastitis), joint (characterized by lameness), and neurological (characterized by chronic nonpurulent meningoencephalomyelitis). There are three levels which try to eliminate the virus: cellular, body, and the flock level. However, SRLVs have ways to counteract these defenses. This review examines some of them. Keywords: small ruminant lentivirus, molecular biology, immune response, genetic resistance
format	article
author	Gomez-Lucia E Barquero N Domenech A
author_facet	Gomez-Lucia E Barquero N Domenech A
author_sort	Gomez-Lucia E
title	Maedi-Visna virus: current perspectives
title_short	Maedi-Visna virus: current perspectives
title_full	Maedi-Visna virus: current perspectives
title_fullStr	Maedi-Visna virus: current perspectives
title_full_unstemmed	Maedi-Visna virus: current perspectives
title_sort	maedi-visna virus: current perspectives
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5f4236a0af754fc6a14243742f5d407f
work_keys_str_mv	AT gomezluciae maedivisnaviruscurrentperspectives AT barqueron maedivisnaviruscurrentperspectives AT domenecha maedivisnaviruscurrentperspectives
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Maedi-Visna virus: current perspectives

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