Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis

Abstract Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal i...

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Autores principales:	Kedir Hussen Hamza, Emma Dunér, Isabel Ulmert, Armando Arias, Daniel Sorobetea, Katharina Lahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f477c0aee734c6986fc32b1f6080948
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spelling	oai:doaj.org-article:5f477c0aee734c6986fc32b1f60809482021-12-02T16:31:50ZMinor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis10.1038/s41598-021-92796-72045-2322https://doaj.org/article/5f477c0aee734c6986fc32b1f60809482021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92796-7https://doaj.org/toc/2045-2322Abstract Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficult to define. Due to the complexity of putatively causative factors, our understanding of such virus-mediated protection is currently very limited. We here set out to better understand the impact that adult enteric infection with rotavirus (RV) might have on the composition of the intestinal microbiome and on the severity of IBD. We found that RV infection neither induced significant long-lasting microbiota community changes in the small or large intestine nor affected the severity of subsequent dextran sulfate sodium-induced colitis. Hence, adult murine RV infection does not exert lasting effects on intestinal homeostasis.Kedir Hussen HamzaEmma DunérIsabel UlmertArmando AriasDaniel SorobeteaKatharina LahlNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kedir Hussen Hamza Emma Dunér Isabel Ulmert Armando Arias Daniel Sorobetea Katharina Lahl Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis
description	Abstract Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficult to define. Due to the complexity of putatively causative factors, our understanding of such virus-mediated protection is currently very limited. We here set out to better understand the impact that adult enteric infection with rotavirus (RV) might have on the composition of the intestinal microbiome and on the severity of IBD. We found that RV infection neither induced significant long-lasting microbiota community changes in the small or large intestine nor affected the severity of subsequent dextran sulfate sodium-induced colitis. Hence, adult murine RV infection does not exert lasting effects on intestinal homeostasis.
format	article
author	Kedir Hussen Hamza Emma Dunér Isabel Ulmert Armando Arias Daniel Sorobetea Katharina Lahl
author_facet	Kedir Hussen Hamza Emma Dunér Isabel Ulmert Armando Arias Daniel Sorobetea Katharina Lahl
author_sort	Kedir Hussen Hamza
title	Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis
title_short	Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis
title_full	Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis
title_fullStr	Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis
title_full_unstemmed	Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis
title_sort	minor alterations in the intestinal microbiota composition upon rotavirus infection do not affect susceptibility to dss colitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f477c0aee734c6986fc32b1f6080948
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Minor alterations in the intestinal microbiota composition upon Rotavirus infection do not affect susceptibility to DSS colitis

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