Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity

Abstract Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models radiation therapy synergizes with checkpoint inhibitors to cure tumors via CD8 T cell responses. To evaluate the immune response initiated b...

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Autores principales: Marka R. Crittenden, Lauren Zebertavage, Gwen Kramer, Shelly Bambina, David Friedman, Victoria Troesch, Tiffany Blair, Jason R. Baird, Alejandro Alice, Michael J. Gough
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5f487b6ccc674a53808df9b8692dc7ec
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