Long-term effectiveness and safety of sirolimus drug-eluting stents

Mahesh Bikkina, Jayanth KoneruSt Joseph Regional Medical Center, Paterson, Seton Hall University, NJ, USAAbstract: The root cause of coronary artery disease is atherosclerosis, ie, intraluminal narrowing (stenosis) of the arteries that supply blood to tissues of the heart. The introduction of the dr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bikkina M, Koneru J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/5f48c0a8c9a04317ab1e277c88dea198
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5f48c0a8c9a04317ab1e277c88dea198
record_format	dspace
spelling	oai:doaj.org-article:5f48c0a8c9a04317ab1e277c88dea1982021-12-02T00:11:57ZLong-term effectiveness and safety of sirolimus drug-eluting stents1179-1470https://doaj.org/article/5f48c0a8c9a04317ab1e277c88dea1982011-08-01T00:00:00Zhttp://www.dovepress.com/long-term-effectiveness-and-safety-of-sirolimus-drug-eluting-stents-a8082https://doaj.org/toc/1179-1470Mahesh Bikkina, Jayanth KoneruSt Joseph Regional Medical Center, Paterson, Seton Hall University, NJ, USAAbstract: The root cause of coronary artery disease is atherosclerosis, ie, intraluminal narrowing (stenosis) of the arteries that supply blood to tissues of the heart. The introduction of the drug-eluting stent over the past decade has revolutionized the field of interventional cardiology. It is used extensively in clinical practice for the treatment of coronary artery disease. The first drug-eluting stent to receive US Food and Drug Administration approval was the sirolimus-eluting stent. Recently, two other stent analogs of sirolimus were approved, ie, the zotarolimus-eluting stent and the everolimus-eluting stent. However, concern has arisen in recent years about the long-term safety and efficacy of drug-eluting stents, due to the occurrence of late adverse clinical events, such as stent thrombosis. This review focuses on clinical studies that have been performed with the sirolimus-eluting stent or its analogs. We discuss the pharmacology, safety, and various therapeutic options that exist when choosing stents for coronary artery disease. Our aim is to provide a thorough review of the long-term efficacy and safety of sirolimus drug-eluting stents, and also to discuss currently approved and promising investigational drug-eluting stents, in an effort to provide insight into how these stents are currently evolving and generate further investigation in this area.Keywords: drug-eluting stent, long-term safety, sirolimus&nbsp;Bikkina MKoneru JDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2011, Iss default, Pp 117-124 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Bikkina M Koneru J Long-term effectiveness and safety of sirolimus drug-eluting stents
description	Mahesh Bikkina, Jayanth KoneruSt Joseph Regional Medical Center, Paterson, Seton Hall University, NJ, USAAbstract: The root cause of coronary artery disease is atherosclerosis, ie, intraluminal narrowing (stenosis) of the arteries that supply blood to tissues of the heart. The introduction of the drug-eluting stent over the past decade has revolutionized the field of interventional cardiology. It is used extensively in clinical practice for the treatment of coronary artery disease. The first drug-eluting stent to receive US Food and Drug Administration approval was the sirolimus-eluting stent. Recently, two other stent analogs of sirolimus were approved, ie, the zotarolimus-eluting stent and the everolimus-eluting stent. However, concern has arisen in recent years about the long-term safety and efficacy of drug-eluting stents, due to the occurrence of late adverse clinical events, such as stent thrombosis. This review focuses on clinical studies that have been performed with the sirolimus-eluting stent or its analogs. We discuss the pharmacology, safety, and various therapeutic options that exist when choosing stents for coronary artery disease. Our aim is to provide a thorough review of the long-term efficacy and safety of sirolimus drug-eluting stents, and also to discuss currently approved and promising investigational drug-eluting stents, in an effort to provide insight into how these stents are currently evolving and generate further investigation in this area.Keywords: drug-eluting stent, long-term safety, sirolimus&nbsp;
format	article
author	Bikkina M Koneru J
author_facet	Bikkina M Koneru J
author_sort	Bikkina M
title	Long-term effectiveness and safety of sirolimus drug-eluting stents
title_short	Long-term effectiveness and safety of sirolimus drug-eluting stents
title_full	Long-term effectiveness and safety of sirolimus drug-eluting stents
title_fullStr	Long-term effectiveness and safety of sirolimus drug-eluting stents
title_full_unstemmed	Long-term effectiveness and safety of sirolimus drug-eluting stents
title_sort	long-term effectiveness and safety of sirolimus drug-eluting stents
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/5f48c0a8c9a04317ab1e277c88dea198
work_keys_str_mv	AT bikkinam longtermeffectivenessandsafetyofsirolimusdrugelutingstents AT koneruj longtermeffectivenessandsafetyofsirolimusdrugelutingstents
_version_	1718403869345579008

Long-term effectiveness and safety of sirolimus drug-eluting stents

Ejemplares similares