Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device

In this study, a novel potentiometric glucose biosensor based on magnetic beads-Nafion-glucose oxidase/graphene oxide/aluminium-doped zinc oxide (MBs-Nafion-GOx/GO/AZO) membranes on a PET substrate with arrayed screen-printed electrodes (SPEs) was proposed. The morphologies, elemental analysis, and...

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Autores principales:	Jung-Chuan Chou, Si-Hong Lin, Po-Yu Kuo, Chih-Hsien Lai, Yu-Hsun Nien, Tsu-Yang Lai, Tzu-Yu Su
Formato:	article
Lenguaje:	EN
Publicado:	IEEE 2019
Materias:	Aluminium-doped zinc oxide (AZO) graphene oxide (GO) magnetic beads (MBs) glucose biosensor screen-printed electrodes (SPEs) microfluidics Electrical engineering. Electronics. Nuclear engineering TK1-9971
Acceso en línea:	https://doaj.org/article/5f49f61c0e6444d38fc486593a428dfe
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spelling	oai:doaj.org-article:5f49f61c0e6444d38fc486593a428dfe2021-11-19T00:01:22ZIntegrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device2168-673410.1109/JEDS.2019.2953093https://doaj.org/article/5f49f61c0e6444d38fc486593a428dfe2019-01-01T00:00:00Zhttps://ieeexplore.ieee.org/document/8896963/https://doaj.org/toc/2168-6734In this study, a novel potentiometric glucose biosensor based on magnetic beads-Nafion-glucose oxidase/graphene oxide/aluminium-doped zinc oxide (MBs-Nafion-GOx/GO/AZO) membranes on a PET substrate with arrayed screen-printed electrodes (SPEs) was proposed. The morphologies, elemental analysis, and surface roughnesses of the sensing membranes were characterized. The sensing parameters of the biosensor were investigated by using the voltage-time (V-T) measurement system, which measured sensitivity, linearity, anti-interference ability, reversibility, temperature effect, and lifetime. A microfluidic device using polydimethylsiloxane (PDMS) was integrated with the V-T measurement system to analyze the response characteristics. The results under static solution and microfluidic flow conditions were compared. The results showed that the average sensitivity and linearity of the biosensor depended on the microfluidic flow rate. The best average sensitivity of the glucose biosensor based on MBs-Nafion-GOx/GO/AZO membranes was 20.35 mV/mM at a flow rate of <inline-formula> <tex-math notation="LaTeX">$15~ \mu \text{L}$ </tex-math></inline-formula>/min.Jung-Chuan ChouSi-Hong LinPo-Yu KuoChih-Hsien LaiYu-Hsun NienTsu-Yang LaiTzu-Yu SuIEEEarticleAluminium-doped zinc oxide (AZO)graphene oxide (GO)magnetic beads (MBs)glucose biosensorscreen-printed electrodes (SPEs)microfluidicsElectrical engineering. Electronics. Nuclear engineeringTK1-9971ENIEEE Journal of the Electron Devices Society, Vol 7, Pp 1151-1160 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aluminium-doped zinc oxide (AZO) graphene oxide (GO) magnetic beads (MBs) glucose biosensor screen-printed electrodes (SPEs) microfluidics Electrical engineering. Electronics. Nuclear engineering TK1-9971
spellingShingle	Aluminium-doped zinc oxide (AZO) graphene oxide (GO) magnetic beads (MBs) glucose biosensor screen-printed electrodes (SPEs) microfluidics Electrical engineering. Electronics. Nuclear engineering TK1-9971 Jung-Chuan Chou Si-Hong Lin Po-Yu Kuo Chih-Hsien Lai Yu-Hsun Nien Tsu-Yang Lai Tzu-Yu Su Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device
description	In this study, a novel potentiometric glucose biosensor based on magnetic beads-Nafion-glucose oxidase/graphene oxide/aluminium-doped zinc oxide (MBs-Nafion-GOx/GO/AZO) membranes on a PET substrate with arrayed screen-printed electrodes (SPEs) was proposed. The morphologies, elemental analysis, and surface roughnesses of the sensing membranes were characterized. The sensing parameters of the biosensor were investigated by using the voltage-time (V-T) measurement system, which measured sensitivity, linearity, anti-interference ability, reversibility, temperature effect, and lifetime. A microfluidic device using polydimethylsiloxane (PDMS) was integrated with the V-T measurement system to analyze the response characteristics. The results under static solution and microfluidic flow conditions were compared. The results showed that the average sensitivity and linearity of the biosensor depended on the microfluidic flow rate. The best average sensitivity of the glucose biosensor based on MBs-Nafion-GOx/GO/AZO membranes was 20.35 mV/mM at a flow rate of <inline-formula> <tex-math notation="LaTeX">$15~ \mu \text{L}$ </tex-math></inline-formula>/min.
format	article
author	Jung-Chuan Chou Si-Hong Lin Po-Yu Kuo Chih-Hsien Lai Yu-Hsun Nien Tsu-Yang Lai Tzu-Yu Su
author_facet	Jung-Chuan Chou Si-Hong Lin Po-Yu Kuo Chih-Hsien Lai Yu-Hsun Nien Tsu-Yang Lai Tzu-Yu Su
author_sort	Jung-Chuan Chou
title	Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device
title_short	Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device
title_full	Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device
title_fullStr	Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device
title_full_unstemmed	Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device
title_sort	integrating a plastic glucose biosensor based on arrayed screen-printed electrodes utilizing magnetic beads with a microfluidic device
publisher	IEEE
publishDate	2019
url	https://doaj.org/article/5f49f61c0e6444d38fc486593a428dfe
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Integrating a Plastic Glucose Biosensor Based on Arrayed Screen-Printed Electrodes Utilizing Magnetic Beads with a Microfluidic Device

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