Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus

Abstract Only a few reports have examined vascular endothelial function before and after educational hospitalization and the factors that affect it in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess vascular endothelial function before and after educational hospita...

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Autores principales:	Yukiko Goshima, Yosuke Okada, Keiichi Torimoto, Yoshihisa Fujino, Yoshiya Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f4a34a4134046148a8c6ffd4e6891e8
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spelling	oai:doaj.org-article:5f4a34a4134046148a8c6ffd4e6891e82021-12-02T18:48:08ZChanges in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus10.1038/s41598-020-72341-82045-2322https://doaj.org/article/5f4a34a4134046148a8c6ffd4e6891e82020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72341-8https://doaj.org/toc/2045-2322Abstract Only a few reports have examined vascular endothelial function before and after educational hospitalization and the factors that affect it in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess vascular endothelial function before and after educational hospitalization and identify factors that affect it. In 65 patients with T2DM who underwent peripheral arterial tonometry (EndoPAT) before and after hospitalization, vascular endothelial function (reactive hyperemia index [RHI]), glucose metabolism, lipid metabolism, and blood pressure were assessed before and after hospitalization. The primary endpoint was hospitalization-induced changes in vascular endothelial function. Educational hospitalization significantly improved the natural logarithmically scaled RHI (L_RHI) from 0.555 ± 0.212 to 0.625 ± 0.245 (p = 0.012). Multivariable logistic regression analysis identified hypoglycemia during hospitalization as the single factor that significantly altered vascular endothelial function (p = 0.019). The odds of achieving normal vascular endothelial function were 0.08 times lower (95% confidence interval, 0.01–0.67) for each episode of hypoglycemia. Furthermore, multivariable analysis identified hypoglycemia during hospitalization as the single factor that worsened L_RHI. Our study showed that educational hospitalization of patients with T2DM improved vascular endothelial function, and that the development of hypoglycemic episodes had a significant negative impact on normalization of vascular endothelial function.Yukiko GoshimaYosuke OkadaKeiichi TorimotoYoshihisa FujinoYoshiya TanakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukiko Goshima Yosuke Okada Keiichi Torimoto Yoshihisa Fujino Yoshiya Tanaka Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
description	Abstract Only a few reports have examined vascular endothelial function before and after educational hospitalization and the factors that affect it in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess vascular endothelial function before and after educational hospitalization and identify factors that affect it. In 65 patients with T2DM who underwent peripheral arterial tonometry (EndoPAT) before and after hospitalization, vascular endothelial function (reactive hyperemia index [RHI]), glucose metabolism, lipid metabolism, and blood pressure were assessed before and after hospitalization. The primary endpoint was hospitalization-induced changes in vascular endothelial function. Educational hospitalization significantly improved the natural logarithmically scaled RHI (L_RHI) from 0.555 ± 0.212 to 0.625 ± 0.245 (p = 0.012). Multivariable logistic regression analysis identified hypoglycemia during hospitalization as the single factor that significantly altered vascular endothelial function (p = 0.019). The odds of achieving normal vascular endothelial function were 0.08 times lower (95% confidence interval, 0.01–0.67) for each episode of hypoglycemia. Furthermore, multivariable analysis identified hypoglycemia during hospitalization as the single factor that worsened L_RHI. Our study showed that educational hospitalization of patients with T2DM improved vascular endothelial function, and that the development of hypoglycemic episodes had a significant negative impact on normalization of vascular endothelial function.
format	article
author	Yukiko Goshima Yosuke Okada Keiichi Torimoto Yoshihisa Fujino Yoshiya Tanaka
author_facet	Yukiko Goshima Yosuke Okada Keiichi Torimoto Yoshihisa Fujino Yoshiya Tanaka
author_sort	Yukiko Goshima
title	Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
title_short	Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
title_full	Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
title_fullStr	Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
title_full_unstemmed	Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
title_sort	changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f4a34a4134046148a8c6ffd4e6891e8
work_keys_str_mv	AT yukikogoshima changesinendothelialfunctionduringeducationalhospitalizationandthecontributortoimprovementofendothelialfunctionintype2diabetesmellitus AT yosukeokada changesinendothelialfunctionduringeducationalhospitalizationandthecontributortoimprovementofendothelialfunctionintype2diabetesmellitus AT keiichitorimoto changesinendothelialfunctionduringeducationalhospitalizationandthecontributortoimprovementofendothelialfunctionintype2diabetesmellitus AT yoshihisafujino changesinendothelialfunctionduringeducationalhospitalizationandthecontributortoimprovementofendothelialfunctionintype2diabetesmellitus AT yoshiyatanaka changesinendothelialfunctionduringeducationalhospitalizationandthecontributortoimprovementofendothelialfunctionintype2diabetesmellitus
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Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus

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