Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity

Abstract In chronic obstructive pulmonary disease (COPD), loss of computed tomography (CT)-measured intercostal mass correlates with spirometric severity. Intercostal muscle ultrasound offers a repeatable and radiation-free alternative, however requires validation. We aimed to determine the reliabil...

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Autores principales:	Peter Wallbridge, Selina M. Parry, Sourav Das, Candice Law, Gary Hammerschlag, Louis Irving, Mark Hew, Daniel Steinfort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Parasternal Intercostals Chronic Obstructive Pulmonary Disease Quadriceps Thickness Muscle Quantity Diaphragm Thickness Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f4aa858bcae45cd9305760d043b0daf
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spelling	oai:doaj.org-article:5f4aa858bcae45cd9305760d043b0daf2021-12-02T15:07:48ZParasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity10.1038/s41598-018-33666-72045-2322https://doaj.org/article/5f4aa858bcae45cd9305760d043b0daf2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33666-7https://doaj.org/toc/2045-2322Abstract In chronic obstructive pulmonary disease (COPD), loss of computed tomography (CT)-measured intercostal mass correlates with spirometric severity. Intercostal muscle ultrasound offers a repeatable and radiation-free alternative, however requires validation. We aimed to determine the reliability of parasternal intercostal muscle ultrasound, and the concurrent validity of parasternal ultrasound with clinicometric parameters. Twenty stable COPD patients underwent ultrasound measurement of thickness and echogenicity of 2nd and 3rd parasternal intercostal muscles, dominant pectoralis major and quadriceps, and diaphragm thickness; spirometry; and chest CT. Intra-rater intraclass correlation (ICC) for ultrasound intercostal thickness was 0.87–0.97 depending on site, with echogenicity ICC 0.63–0.91. Inter-rater ICC was fair to excellent. Ultrasound intercostal thickness moderately correlated with FEV1% predicted (r = 0.33) and quadriceps thickness (r = 0.31). Echogenicity correlated negatively with FEV1% predicted (r = −0.32). CT-measured lateral intercostal mass correlate negatively with parasternal ultrasound intercostal thickness. These data confirm ultrasound of parasternal intercostal musculature is reproducible. Lower intercostal muscle quantity and quality reflects greater COPD spirometric severity. This novel tool may have biomarker potential for both the systemic effects of COPD on muscle as well as local disruption of respiratory mechanics. The negative correlation between CT and ultrasound measurements may reflect complex site-dependent interactions between respiratory muscles and the chest wall.Peter WallbridgeSelina M. ParrySourav DasCandice LawGary HammerschlagLouis IrvingMark HewDaniel SteinfortNature PortfolioarticleParasternal IntercostalsChronic Obstructive Pulmonary DiseaseQuadriceps ThicknessMuscle QuantityDiaphragm ThicknessMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parasternal Intercostals Chronic Obstructive Pulmonary Disease Quadriceps Thickness Muscle Quantity Diaphragm Thickness Medicine R Science Q
spellingShingle	Parasternal Intercostals Chronic Obstructive Pulmonary Disease Quadriceps Thickness Muscle Quantity Diaphragm Thickness Medicine R Science Q Peter Wallbridge Selina M. Parry Sourav Das Candice Law Gary Hammerschlag Louis Irving Mark Hew Daniel Steinfort Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
description	Abstract In chronic obstructive pulmonary disease (COPD), loss of computed tomography (CT)-measured intercostal mass correlates with spirometric severity. Intercostal muscle ultrasound offers a repeatable and radiation-free alternative, however requires validation. We aimed to determine the reliability of parasternal intercostal muscle ultrasound, and the concurrent validity of parasternal ultrasound with clinicometric parameters. Twenty stable COPD patients underwent ultrasound measurement of thickness and echogenicity of 2nd and 3rd parasternal intercostal muscles, dominant pectoralis major and quadriceps, and diaphragm thickness; spirometry; and chest CT. Intra-rater intraclass correlation (ICC) for ultrasound intercostal thickness was 0.87–0.97 depending on site, with echogenicity ICC 0.63–0.91. Inter-rater ICC was fair to excellent. Ultrasound intercostal thickness moderately correlated with FEV1% predicted (r = 0.33) and quadriceps thickness (r = 0.31). Echogenicity correlated negatively with FEV1% predicted (r = −0.32). CT-measured lateral intercostal mass correlate negatively with parasternal ultrasound intercostal thickness. These data confirm ultrasound of parasternal intercostal musculature is reproducible. Lower intercostal muscle quantity and quality reflects greater COPD spirometric severity. This novel tool may have biomarker potential for both the systemic effects of COPD on muscle as well as local disruption of respiratory mechanics. The negative correlation between CT and ultrasound measurements may reflect complex site-dependent interactions between respiratory muscles and the chest wall.
format	article
author	Peter Wallbridge Selina M. Parry Sourav Das Candice Law Gary Hammerschlag Louis Irving Mark Hew Daniel Steinfort
author_facet	Peter Wallbridge Selina M. Parry Sourav Das Candice Law Gary Hammerschlag Louis Irving Mark Hew Daniel Steinfort
author_sort	Peter Wallbridge
title	Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
title_short	Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
title_full	Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
title_fullStr	Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
title_full_unstemmed	Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
title_sort	parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5f4aa858bcae45cd9305760d043b0daf
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Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity

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