The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.

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Detalles Bibliográficos
Autores principales: A. V. Shah, G. M. Birdsey, C. Peghaire, M. E. Pitulescu, N. P. Dufton, Y. Yang, I. Weinberg, L. Osuna Almagro, L. Payne, J. C. Mason, H. Gerhardt, R. H. Adams, A. M. Randi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/5f4b6819b7ab45719c0100c6dc529987
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Descripción
Sumario:Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.

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