The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.

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Autores principales: A. V. Shah, G. M. Birdsey, C. Peghaire, M. E. Pitulescu, N. P. Dufton, Y. Yang, I. Weinberg, L. Osuna Almagro, L. Payne, J. C. Mason, H. Gerhardt, R. H. Adams, A. M. Randi
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5f4b6819b7ab45719c0100c6dc529987
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spelling oai:doaj.org-article:5f4b6819b7ab45719c0100c6dc5299872021-12-02T14:42:45ZThe endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability10.1038/ncomms160022041-1723https://doaj.org/article/5f4b6819b7ab45719c0100c6dc5299872017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16002https://doaj.org/toc/2041-1723Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.A. V. ShahG. M. BirdseyC. PeghaireM. E. PitulescuN. P. DuftonY. YangI. WeinbergL. Osuna AlmagroL. PayneJ. C. MasonH. GerhardtR. H. AdamsA. M. RandiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. V. Shah
G. M. Birdsey
C. Peghaire
M. E. Pitulescu
N. P. Dufton
Y. Yang
I. Weinberg
L. Osuna Almagro
L. Payne
J. C. Mason
H. Gerhardt
R. H. Adams
A. M. Randi
The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
description Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.
format article
author A. V. Shah
G. M. Birdsey
C. Peghaire
M. E. Pitulescu
N. P. Dufton
Y. Yang
I. Weinberg
L. Osuna Almagro
L. Payne
J. C. Mason
H. Gerhardt
R. H. Adams
A. M. Randi
author_facet A. V. Shah
G. M. Birdsey
C. Peghaire
M. E. Pitulescu
N. P. Dufton
Y. Yang
I. Weinberg
L. Osuna Almagro
L. Payne
J. C. Mason
H. Gerhardt
R. H. Adams
A. M. Randi
author_sort A. V. Shah
title The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
title_short The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
title_full The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
title_fullStr The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
title_full_unstemmed The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
title_sort endothelial transcription factor erg mediates angiopoietin-1-dependent control of notch signalling and vascular stability
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5f4b6819b7ab45719c0100c6dc529987
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