Influence of wiring cost on the large-scale architecture of human cortical connectivity.

In the past two decades some fundamental properties of cortical connectivity have been discovered: small-world structure, pronounced hierarchical and modular organisation, and strong core and rich-club structures. A common assumption when interpreting results of this kind is that the observed struct...

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Autores principales:	David Samu, Anil K Seth, Thomas Nowotny
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5f4f6766607a47d19fd6b85055dc323f
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spelling	oai:doaj.org-article:5f4f6766607a47d19fd6b85055dc323f2021-11-18T05:53:00ZInfluence of wiring cost on the large-scale architecture of human cortical connectivity.1553-734X1553-735810.1371/journal.pcbi.1003557https://doaj.org/article/5f4f6766607a47d19fd6b85055dc323f2014-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24699277/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358In the past two decades some fundamental properties of cortical connectivity have been discovered: small-world structure, pronounced hierarchical and modular organisation, and strong core and rich-club structures. A common assumption when interpreting results of this kind is that the observed structural properties are present to enable the brain's function. However, the brain is also embedded into the limited space of the skull and its wiring has associated developmental and metabolic costs. These basic physical and economic aspects place separate, often conflicting, constraints on the brain's connectivity, which must be characterized in order to understand the true relationship between brain structure and function. To address this challenge, here we ask which, and to what extent, aspects of the structural organisation of the brain are conserved if we preserve specific spatial and topological properties of the brain but otherwise randomise its connectivity. We perform a comparative analysis of a connectivity map of the cortical connectome both on high- and low-resolutions utilising three different types of surrogate networks: spatially unconstrained ('random'), connection length preserving ('spatial'), and connection length optimised ('reduced') surrogates. We find that unconstrained randomisation markedly diminishes all investigated architectural properties of cortical connectivity. By contrast, spatial and reduced surrogates largely preserve most properties and, interestingly, often more so in the reduced surrogates. Specifically, our results suggest that the cortical network is less tightly integrated than its spatial constraints would allow, but more strongly segregated than its spatial constraints would necessitate. We additionally find that hierarchical organisation and rich-club structure of the cortical connectivity are largely preserved in spatial and reduced surrogates and hence may be partially attributable to cortical wiring constraints. In contrast, the high modularity and strong s-core of the high-resolution cortical network are significantly stronger than in the surrogates, underlining their potential functional relevance in the brain.David SamuAnil K SethThomas NowotnyPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 4, p e1003557 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 David Samu Anil K Seth Thomas Nowotny Influence of wiring cost on the large-scale architecture of human cortical connectivity.
description	In the past two decades some fundamental properties of cortical connectivity have been discovered: small-world structure, pronounced hierarchical and modular organisation, and strong core and rich-club structures. A common assumption when interpreting results of this kind is that the observed structural properties are present to enable the brain's function. However, the brain is also embedded into the limited space of the skull and its wiring has associated developmental and metabolic costs. These basic physical and economic aspects place separate, often conflicting, constraints on the brain's connectivity, which must be characterized in order to understand the true relationship between brain structure and function. To address this challenge, here we ask which, and to what extent, aspects of the structural organisation of the brain are conserved if we preserve specific spatial and topological properties of the brain but otherwise randomise its connectivity. We perform a comparative analysis of a connectivity map of the cortical connectome both on high- and low-resolutions utilising three different types of surrogate networks: spatially unconstrained ('random'), connection length preserving ('spatial'), and connection length optimised ('reduced') surrogates. We find that unconstrained randomisation markedly diminishes all investigated architectural properties of cortical connectivity. By contrast, spatial and reduced surrogates largely preserve most properties and, interestingly, often more so in the reduced surrogates. Specifically, our results suggest that the cortical network is less tightly integrated than its spatial constraints would allow, but more strongly segregated than its spatial constraints would necessitate. We additionally find that hierarchical organisation and rich-club structure of the cortical connectivity are largely preserved in spatial and reduced surrogates and hence may be partially attributable to cortical wiring constraints. In contrast, the high modularity and strong s-core of the high-resolution cortical network are significantly stronger than in the surrogates, underlining their potential functional relevance in the brain.
format	article
author	David Samu Anil K Seth Thomas Nowotny
author_facet	David Samu Anil K Seth Thomas Nowotny
author_sort	David Samu
title	Influence of wiring cost on the large-scale architecture of human cortical connectivity.
title_short	Influence of wiring cost on the large-scale architecture of human cortical connectivity.
title_full	Influence of wiring cost on the large-scale architecture of human cortical connectivity.
title_fullStr	Influence of wiring cost on the large-scale architecture of human cortical connectivity.
title_full_unstemmed	Influence of wiring cost on the large-scale architecture of human cortical connectivity.
title_sort	influence of wiring cost on the large-scale architecture of human cortical connectivity.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5f4f6766607a47d19fd6b85055dc323f
work_keys_str_mv	AT davidsamu influenceofwiringcostonthelargescalearchitectureofhumancorticalconnectivity AT anilkseth influenceofwiringcostonthelargescalearchitectureofhumancorticalconnectivity AT thomasnowotny influenceofwiringcostonthelargescalearchitectureofhumancorticalconnectivity
_version_	1718424668935815168

Influence of wiring cost on the large-scale architecture of human cortical connectivity.

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