Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or me...

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Autores principales:	Nader Aboul-Fettouh, Daniel Morse, Jigar Patel, Michael R. Migden
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	cutaneous squamous cell carcinoma systemic therapies immunotherapy tumor response cSCC advanced cSCC Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/5f50329870c5454eb63b6b30727bf577
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spelling	oai:doaj.org-article:5f50329870c5454eb63b6b30727bf5772021-11-17T08:27:36ZImmunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma10.5826/dpc.11S2a169S2160-9381https://doaj.org/article/5f50329870c5454eb63b6b30727bf5772021-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1945https://doaj.org/toc/2160-9381 Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targeted approaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease. Nader Aboul-FettouhDaniel MorseJigar PatelMichael R. Migden Mattioli1885articlecutaneous squamous cell carcinomasystemic therapiesimmunotherapytumor responsecSCCadvanced cSCCDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 11, Iss S2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cutaneous squamous cell carcinoma systemic therapies immunotherapy tumor response cSCC advanced cSCC Dermatology RL1-803
spellingShingle	cutaneous squamous cell carcinoma systemic therapies immunotherapy tumor response cSCC advanced cSCC Dermatology RL1-803 Nader Aboul-Fettouh Daniel Morse Jigar Patel Michael R. Migden Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
description	Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targeted approaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease.
format	article
author	Nader Aboul-Fettouh Daniel Morse Jigar Patel Michael R. Migden
author_facet	Nader Aboul-Fettouh Daniel Morse Jigar Patel Michael R. Migden
author_sort	Nader Aboul-Fettouh
title	Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
title_short	Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
title_full	Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
title_fullStr	Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
title_full_unstemmed	Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma
title_sort	immunotherapy and systemic treatment of cutaneous squamous cell carcinoma
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/5f50329870c5454eb63b6b30727bf577
work_keys_str_mv	AT naderaboulfettouh immunotherapyandsystemictreatmentofcutaneoussquamouscellcarcinoma AT danielmorse immunotherapyandsystemictreatmentofcutaneoussquamouscellcarcinoma AT jigarpatel immunotherapyandsystemictreatmentofcutaneoussquamouscellcarcinoma AT michaelrmigden immunotherapyandsystemictreatmentofcutaneoussquamouscellcarcinoma
_version_	1718425800586297344

Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma

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