Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.

A progressive increase in the incidence of thyroid cancer (TC) has been reported over the last few decades. This either reflects the increased number of newly discovered and accurately selected thyroid nodules with more sensitive technologies and a relative more potent carcinogenic effect of pathoge...

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Autores principales:	Angelo Carpi, Giuseppe Rossi, Rossana Romani, Giancarlo Di Coscio, Andrea Nicolini, Tommaso Simoncini, Matteo Russo, Jeffrey Mechanick
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f51c42bf46542c39f69ae673f924a37
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spelling	oai:doaj.org-article:5f51c42bf46542c39f69ae673f924a372021-11-18T08:10:32ZAre risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.1932-620310.1371/journal.pone.0047758https://doaj.org/article/5f51c42bf46542c39f69ae673f924a372012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118895/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A progressive increase in the incidence of thyroid cancer (TC) has been reported over the last few decades. This either reflects the increased number of newly discovered and accurately selected thyroid nodules with more sensitive technologies and a relative more potent carcinogenic effect of pathogenetic factors in malignant, but not benign nodules. This observational time-trend study addresses this issue by analysing the proportion of TC within 8411 consecutive thyroid nodule (TN) patients evaluated in Pisa by the same pathology Department and individual clinician over a four-decade period. From 1972 to 1979 surgery was used to detect TC among the TN patients: 1140 TN patients were operated on and 35 cancers were detected (3.1% of all the TN patients). Subsequently, needle aspiration techniques were used to select TN for surgery. From 1980 to 1992, 5403 TN patients were examined, 483 were selected for surgery, and 150 cancers were found (2.8% of all the TN patients). From 1993 to 2010, 1568 TN patients were examined, 143 were selected for surgery, and 46 cancers were found (2.9% of all the TN patients). Therefore, in the University Hospital of Pisa, and independent of preoperative TN selection protocols, these proportions of TN eventually found to harbor TC remained statistically unchanged over 40 years (p = 0.810). This finding suggests that pathogenic risk factors and more sensitive diagnostic technologies did not differentially affect the incidence of TN and TC.Angelo CarpiGiuseppe RossiRossana RomaniGiancarlo Di CoscioAndrea NicoliniTommaso SimonciniMatteo RussoJeffrey MechanickPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47758 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelo Carpi Giuseppe Rossi Rossana Romani Giancarlo Di Coscio Andrea Nicolini Tommaso Simoncini Matteo Russo Jeffrey Mechanick Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.
description	A progressive increase in the incidence of thyroid cancer (TC) has been reported over the last few decades. This either reflects the increased number of newly discovered and accurately selected thyroid nodules with more sensitive technologies and a relative more potent carcinogenic effect of pathogenetic factors in malignant, but not benign nodules. This observational time-trend study addresses this issue by analysing the proportion of TC within 8411 consecutive thyroid nodule (TN) patients evaluated in Pisa by the same pathology Department and individual clinician over a four-decade period. From 1972 to 1979 surgery was used to detect TC among the TN patients: 1140 TN patients were operated on and 35 cancers were detected (3.1% of all the TN patients). Subsequently, needle aspiration techniques were used to select TN for surgery. From 1980 to 1992, 5403 TN patients were examined, 483 were selected for surgery, and 150 cancers were found (2.8% of all the TN patients). From 1993 to 2010, 1568 TN patients were examined, 143 were selected for surgery, and 46 cancers were found (2.9% of all the TN patients). Therefore, in the University Hospital of Pisa, and independent of preoperative TN selection protocols, these proportions of TN eventually found to harbor TC remained statistically unchanged over 40 years (p = 0.810). This finding suggests that pathogenic risk factors and more sensitive diagnostic technologies did not differentially affect the incidence of TN and TC.
format	article
author	Angelo Carpi Giuseppe Rossi Rossana Romani Giancarlo Di Coscio Andrea Nicolini Tommaso Simoncini Matteo Russo Jeffrey Mechanick
author_facet	Angelo Carpi Giuseppe Rossi Rossana Romani Giancarlo Di Coscio Andrea Nicolini Tommaso Simoncini Matteo Russo Jeffrey Mechanick
author_sort	Angelo Carpi
title	Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.
title_short	Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.
title_full	Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.
title_fullStr	Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.
title_full_unstemmed	Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.
title_sort	are risk factors common to thyroid cancer and nodule? a forty years observational time-trend study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5f51c42bf46542c39f69ae673f924a37
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Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.

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