Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation

Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation

Synaptic adhesion molecules mediate synaptic differentiation and formation. Here the authors present the structures of the synaptic adhesion molecule SALM5 alone and in complex with the LAR family receptor protein tyrosine phosphatase (LAR-RPTP) PTPδ, which reveals how SALM5 dimerization facilitates...

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Autores principales: Zhaohan Lin, Jianmei Liu, Huandi Ding, Fei Xu, Heli Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5f5a1be86db94d6280556e761c0a9872
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spelling oai:doaj.org-article:5f5a1be86db94d6280556e761c0a98722021-12-02T16:50:07ZStructural basis of SALM5-induced PTPδ dimerization for synaptic differentiation10.1038/s41467-017-02414-22041-1723https://doaj.org/article/5f5a1be86db94d6280556e761c0a98722018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02414-2https://doaj.org/toc/2041-1723Synaptic adhesion molecules mediate synaptic differentiation and formation. Here the authors present the structures of the synaptic adhesion molecule SALM5 alone and in complex with the LAR family receptor protein tyrosine phosphatase (LAR-RPTP) PTPδ, which reveals how SALM5 dimerization facilitates higher-order signaling assembly of LAR-RPTPs.Zhaohan LinJianmei LiuHuandi DingFei XuHeli LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhaohan Lin
Jianmei Liu
Huandi Ding
Fei Xu
Heli Liu
Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation
description Synaptic adhesion molecules mediate synaptic differentiation and formation. Here the authors present the structures of the synaptic adhesion molecule SALM5 alone and in complex with the LAR family receptor protein tyrosine phosphatase (LAR-RPTP) PTPδ, which reveals how SALM5 dimerization facilitates higher-order signaling assembly of LAR-RPTPs.
format article
author Zhaohan Lin
Jianmei Liu
Huandi Ding
Fei Xu
Heli Liu
author_facet Zhaohan Lin
Jianmei Liu
Huandi Ding
Fei Xu
Heli Liu
author_sort Zhaohan Lin
title Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation
title_short Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation
title_full Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation
title_fullStr Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation
title_full_unstemmed Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation
title_sort structural basis of salm5-induced ptpδ dimerization for synaptic differentiation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5f5a1be86db94d6280556e761c0a9872
work_keys_str_mv AT zhaohanlin structuralbasisofsalm5inducedptpddimerizationforsynapticdifferentiation
AT jianmeiliu structuralbasisofsalm5inducedptpddimerizationforsynapticdifferentiation
AT huandiding structuralbasisofsalm5inducedptpddimerizationforsynapticdifferentiation
AT feixu structuralbasisofsalm5inducedptpddimerizationforsynapticdifferentiation
AT heliliu structuralbasisofsalm5inducedptpddimerizationforsynapticdifferentiation
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