GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

In breast cancer GATA3 is known to be frequently mutated, but the function of these mutations is unclear. Here, the authors utilise CRISPR-Cas9 to model frame-shift mutations in zinc finger 2 of GATA3, highlighting that GATA3 mutation can have gain- or loss-of function effects in breast cancer.

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Autores principales:	Motoki Takaku, Sara A. Grimm, John D. Roberts, Kaliopi Chrysovergis, Brian D. Bennett, Page Myers, Lalith Perera, Charles J. Tucker, Charles M. Perou, Paul A. Wade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f5be941e8644deb8f837c3cb577731d
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spelling	oai:doaj.org-article:5f5be941e8644deb8f837c3cb577731d2021-12-02T17:32:15ZGATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network10.1038/s41467-018-03478-42041-1723https://doaj.org/article/5f5be941e8644deb8f837c3cb577731d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03478-4https://doaj.org/toc/2041-1723In breast cancer GATA3 is known to be frequently mutated, but the function of these mutations is unclear. Here, the authors utilise CRISPR-Cas9 to model frame-shift mutations in zinc finger 2 of GATA3, highlighting that GATA3 mutation can have gain- or loss-of function effects in breast cancer.Motoki TakakuSara A. GrimmJohn D. RobertsKaliopi ChrysovergisBrian D. BennettPage MyersLalith PereraCharles J. TuckerCharles M. PerouPaul A. WadeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Motoki Takaku Sara A. Grimm John D. Roberts Kaliopi Chrysovergis Brian D. Bennett Page Myers Lalith Perera Charles J. Tucker Charles M. Perou Paul A. Wade GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
description	In breast cancer GATA3 is known to be frequently mutated, but the function of these mutations is unclear. Here, the authors utilise CRISPR-Cas9 to model frame-shift mutations in zinc finger 2 of GATA3, highlighting that GATA3 mutation can have gain- or loss-of function effects in breast cancer.
format	article
author	Motoki Takaku Sara A. Grimm John D. Roberts Kaliopi Chrysovergis Brian D. Bennett Page Myers Lalith Perera Charles J. Tucker Charles M. Perou Paul A. Wade
author_facet	Motoki Takaku Sara A. Grimm John D. Roberts Kaliopi Chrysovergis Brian D. Bennett Page Myers Lalith Perera Charles J. Tucker Charles M. Perou Paul A. Wade
author_sort	Motoki Takaku
title	GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
title_short	GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
title_full	GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
title_fullStr	GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
title_full_unstemmed	GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
title_sort	gata3 zinc finger 2 mutations reprogram the breast cancer transcriptional network
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5f5be941e8644deb8f837c3cb577731d
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GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

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