Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial

Abstract Long‐term stress can lead to long‐term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone‐sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and...

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Autores principales:	Maja Arena Jørgensen, Karen Johanne Pallesen, Lone Overby Fjorback, Lise Juul
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/5f5bfc2c13e9479b9813e2318a819cc5
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spelling	oai:doaj.org-article:5f5bfc2c13e9479b9813e2318a819cc52021-11-19T17:51:35ZEffect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial1752-80621752-805410.1111/cts.13100https://doaj.org/article/5f5bfc2c13e9479b9813e2318a819cc52021-11-01T00:00:00Zhttps://doi.org/10.1111/cts.13100https://doaj.org/toc/1752-8054https://doaj.org/toc/1752-8062Abstract Long‐term stress can lead to long‐term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone‐sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and may be protective during stress. The program “Mindfulness‐Based Stress Reduction” (MBSR) has shown to have positive effects on stress. The present study examined a possible effect of MBSR on DHEAS in plasma compared to a waiting list and a locally developed stress reduction program (LSR) in people with self‐reported stress. The study was a three‐armed randomized controlled trial conducted in a municipal health care center in Denmark. It included 71 participants with self‐reported stress randomized to either MBSR (n = 24) or LSR (n = 23), or a waiting list (n = 24). Blood samples were collected at baseline and at 12 weeks follow‐up to estimate effects of MBSR on DHEAS. The effect of MBSR on DHEAS was statistically significant compared to both the waiting list and LSR. We found a mean effect of 0.70 µmol/L (95% confidence interval [CI] = 0.18–1.22) higher DHEAS in the MBSR group compared with the waiting list group and a mean effect of 0.54 µmol/L (95% CI = 0.04–1.05) higher DHEAS in the MBSR group compared with the LSR group. Findings indicate an effect on DHEAS of the MBSR program compared to a waiting list and LSR program in people with self‐reported stress. However, we consider our findings hypothesis‐generating and validation by future studies is essential.Maja Arena JørgensenKaren Johanne PallesenLone Overby FjorbackLise JuulWileyarticleTherapeutics. PharmacologyRM1-950Public aspects of medicineRA1-1270ENClinical and Translational Science, Vol 14, Iss 6, Pp 2360-2369 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
spellingShingle	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270 Maja Arena Jørgensen Karen Johanne Pallesen Lone Overby Fjorback Lise Juul Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial
description	Abstract Long‐term stress can lead to long‐term increased cortisol plasma levels, which increases the risk of numerous diseases. Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone‐sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of cortisol and may be protective during stress. The program “Mindfulness‐Based Stress Reduction” (MBSR) has shown to have positive effects on stress. The present study examined a possible effect of MBSR on DHEAS in plasma compared to a waiting list and a locally developed stress reduction program (LSR) in people with self‐reported stress. The study was a three‐armed randomized controlled trial conducted in a municipal health care center in Denmark. It included 71 participants with self‐reported stress randomized to either MBSR (n = 24) or LSR (n = 23), or a waiting list (n = 24). Blood samples were collected at baseline and at 12 weeks follow‐up to estimate effects of MBSR on DHEAS. The effect of MBSR on DHEAS was statistically significant compared to both the waiting list and LSR. We found a mean effect of 0.70 µmol/L (95% confidence interval [CI] = 0.18–1.22) higher DHEAS in the MBSR group compared with the waiting list group and a mean effect of 0.54 µmol/L (95% CI = 0.04–1.05) higher DHEAS in the MBSR group compared with the LSR group. Findings indicate an effect on DHEAS of the MBSR program compared to a waiting list and LSR program in people with self‐reported stress. However, we consider our findings hypothesis‐generating and validation by future studies is essential.
format	article
author	Maja Arena Jørgensen Karen Johanne Pallesen Lone Overby Fjorback Lise Juul
author_facet	Maja Arena Jørgensen Karen Johanne Pallesen Lone Overby Fjorback Lise Juul
author_sort	Maja Arena Jørgensen
title	Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial
title_short	Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial
title_full	Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial
title_fullStr	Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial
title_full_unstemmed	Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial
title_sort	effect of mindfulness‐based stress reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. a randomized trial
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/5f5bfc2c13e9479b9813e2318a819cc5
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Effect of Mindfulness‐Based Stress Reduction on dehydroepiandrosterone‐sulfate in adults with self‐reported stress. A randomized trial

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