Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

The NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the m...

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Autores principales:	Wenjie Guo, Wen Liu, Zhen Chen, Yanhong Gu, Shuang Peng, Lihong Shen, Yan Shen, Xingqi Wang, Gen-Sheng Feng, Yang Sun, Qiang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f5f911797374397b243eef9239a9a18
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spelling	oai:doaj.org-article:5f5f911797374397b243eef9239a9a182021-12-02T14:42:17ZTyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis10.1038/s41467-017-02351-02041-1723https://doaj.org/article/5f5f911797374397b243eef9239a9a182017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02351-0https://doaj.org/toc/2041-1723The NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the mitochondria and preventing release of proinflammatory mitochondrial DNA and ROS.Wenjie GuoWen LiuZhen ChenYanhong GuShuang PengLihong ShenYan ShenXingqi WangGen-Sheng FengYang SunQiang XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjie Guo Wen Liu Zhen Chen Yanhong Gu Shuang Peng Lihong Shen Yan Shen Xingqi Wang Gen-Sheng Feng Yang Sun Qiang Xu Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
description	The NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the mitochondria and preventing release of proinflammatory mitochondrial DNA and ROS.
format	article
author	Wenjie Guo Wen Liu Zhen Chen Yanhong Gu Shuang Peng Lihong Shen Yan Shen Xingqi Wang Gen-Sheng Feng Yang Sun Qiang Xu
author_facet	Wenjie Guo Wen Liu Zhen Chen Yanhong Gu Shuang Peng Lihong Shen Yan Shen Xingqi Wang Gen-Sheng Feng Yang Sun Qiang Xu
author_sort	Wenjie Guo
title	Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
title_short	Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
title_full	Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
title_fullStr	Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
title_full_unstemmed	Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
title_sort	tyrosine phosphatase shp2 negatively regulates nlrp3 inflammasome activation via ant1-dependent mitochondrial homeostasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5f5f911797374397b243eef9239a9a18
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Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

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