Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
Brachytherapy is expected to be a solution to the side effect of other cancer therapy methods. This study aims to synthesize ferrofluids (FF)-Chitosan-Au (so-called cold synthesis) as the initial step before using 198Au that is expected to be a targeted and controllable brachytherapy agent. In this...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Department of Chemistry, Universitas Gadjah Mada
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/5f60e1bd39694b10a29a253ef6b64358 |
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| Sumario: | Brachytherapy is expected to be a solution to the side effect of other cancer therapy methods. This study aims to synthesize ferrofluids (FF)-Chitosan-Au (so-called cold synthesis) as the initial step before using 198Au that is expected to be a targeted and controllable brachytherapy agent. In this research, the preparation of FF-Chitosan was done by the co-precipitation method. Furthermore, FF-Chitosan-Au was produced via self-assembly by the adsorption method. The adsorption followed the Langmuir model with a maximum capacity of 30.24 mg Au/g FF-Chitosan. The X-Ray Diffractometion (XRD) of FF-Chitosan-Au confirms the existence of Au. Particle Size Analyzer (PSA) indicates FF-Chitosan-Au has an average size of 82.93 nm with a polydispersity index of 0.175. Morphological and distribution analysis of nanoparticles using Scanning Electron Microscope (SEM) shows that nanoparticles have a homogenous spherical shape. Vibrating Sample Magnetometer (VSM) measurement confirms the superparamagnetic properties of FF-Chitosan and FF-Chitosan-Au with a saturated magnetization of 80.48 and 74.52 emu/g, respectively. The overall results are associated with biomedical requirements, such as high saturation magnetization and good polydispersity. The synthesis can also be applied to produce FF-Chitosan-198Au that has great potential as a brachytherapy agent, which will reduce the nuclear waste and potential danger of radiation received by workers during synthesis. |
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