Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate

Brachytherapy is expected to be a solution to the side effect of other cancer therapy methods. This study aims to synthesize ferrofluids (FF)-Chitosan-Au (so-called cold synthesis) as the initial step before using 198Au that is expected to be a targeted and controllable brachytherapy agent. In this...

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Autores principales:	Muflikhah Muflikhah, Ahmad Marzuki Ramadhan, Maria Christina Prihatiningsih, Mujamilah Mujamilah, Aloma Karo Karo
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	ferrofluids magnetic nanoparticle adsorption chitosan-gold, brachytherapy Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5f60e1bd39694b10a29a253ef6b64358
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spelling	oai:doaj.org-article:5f60e1bd39694b10a29a253ef6b643582021-12-02T18:41:46ZSynthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate1411-94202460-157810.22146/ijc.62191https://doaj.org/article/5f60e1bd39694b10a29a253ef6b643582021-07-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/62191https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578Brachytherapy is expected to be a solution to the side effect of other cancer therapy methods. This study aims to synthesize ferrofluids (FF)-Chitosan-Au (so-called cold synthesis) as the initial step before using 198Au that is expected to be a targeted and controllable brachytherapy agent. In this research, the preparation of FF-Chitosan was done by the co-precipitation method. Furthermore, FF-Chitosan-Au was produced via self-assembly by the adsorption method. The adsorption followed the Langmuir model with a maximum capacity of 30.24 mg Au/g FF-Chitosan. The X-Ray Diffractometion (XRD) of FF-Chitosan-Au confirms the existence of Au. Particle Size Analyzer (PSA) indicates FF-Chitosan-Au has an average size of 82.93 nm with a polydispersity index of 0.175. Morphological and distribution analysis of nanoparticles using Scanning Electron Microscope (SEM) shows that nanoparticles have a homogenous spherical shape. Vibrating Sample Magnetometer (VSM) measurement confirms the superparamagnetic properties of FF-Chitosan and FF-Chitosan-Au with a saturated magnetization of 80.48 and 74.52 emu/g, respectively. The overall results are associated with biomedical requirements, such as high saturation magnetization and good polydispersity. The synthesis can also be applied to produce FF-Chitosan-198Au that has great potential as a brachytherapy agent, which will reduce the nuclear waste and potential danger of radiation received by workers during synthesis.Muflikhah MuflikhahAhmad Marzuki RamadhanMaria Christina PrihatiningsihMujamilah MujamilahAloma Karo KaroDepartment of Chemistry, Universitas Gadjah Madaarticleferrofluidsmagnetic nanoparticleadsorptionchitosan-gold, brachytherapyChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 4, Pp 891-900 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferrofluids magnetic nanoparticle adsorption chitosan-gold, brachytherapy Chemistry QD1-999
spellingShingle	ferrofluids magnetic nanoparticle adsorption chitosan-gold, brachytherapy Chemistry QD1-999 Muflikhah Muflikhah Ahmad Marzuki Ramadhan Maria Christina Prihatiningsih Mujamilah Mujamilah Aloma Karo Karo Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
description	Brachytherapy is expected to be a solution to the side effect of other cancer therapy methods. This study aims to synthesize ferrofluids (FF)-Chitosan-Au (so-called cold synthesis) as the initial step before using 198Au that is expected to be a targeted and controllable brachytherapy agent. In this research, the preparation of FF-Chitosan was done by the co-precipitation method. Furthermore, FF-Chitosan-Au was produced via self-assembly by the adsorption method. The adsorption followed the Langmuir model with a maximum capacity of 30.24 mg Au/g FF-Chitosan. The X-Ray Diffractometion (XRD) of FF-Chitosan-Au confirms the existence of Au. Particle Size Analyzer (PSA) indicates FF-Chitosan-Au has an average size of 82.93 nm with a polydispersity index of 0.175. Morphological and distribution analysis of nanoparticles using Scanning Electron Microscope (SEM) shows that nanoparticles have a homogenous spherical shape. Vibrating Sample Magnetometer (VSM) measurement confirms the superparamagnetic properties of FF-Chitosan and FF-Chitosan-Au with a saturated magnetization of 80.48 and 74.52 emu/g, respectively. The overall results are associated with biomedical requirements, such as high saturation magnetization and good polydispersity. The synthesis can also be applied to produce FF-Chitosan-198Au that has great potential as a brachytherapy agent, which will reduce the nuclear waste and potential danger of radiation received by workers during synthesis.
format	article
author	Muflikhah Muflikhah Ahmad Marzuki Ramadhan Maria Christina Prihatiningsih Mujamilah Mujamilah Aloma Karo Karo
author_facet	Muflikhah Muflikhah Ahmad Marzuki Ramadhan Maria Christina Prihatiningsih Mujamilah Mujamilah Aloma Karo Karo
author_sort	Muflikhah Muflikhah
title	Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
title_short	Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
title_full	Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
title_fullStr	Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
title_full_unstemmed	Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate
title_sort	synthesis and characterization of ferrofluid-chitosan-au nanoparticles as brachytherapy agent candidate
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/5f60e1bd39694b10a29a253ef6b64358
work_keys_str_mv	AT muflikhahmuflikhah synthesisandcharacterizationofferrofluidchitosanaunanoparticlesasbrachytherapyagentcandidate AT ahmadmarzukiramadhan synthesisandcharacterizationofferrofluidchitosanaunanoparticlesasbrachytherapyagentcandidate AT mariachristinaprihatiningsih synthesisandcharacterizationofferrofluidchitosanaunanoparticlesasbrachytherapyagentcandidate AT mujamilahmujamilah synthesisandcharacterizationofferrofluidchitosanaunanoparticlesasbrachytherapyagentcandidate AT alomakarokaro synthesisandcharacterizationofferrofluidchitosanaunanoparticlesasbrachytherapyagentcandidate
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Synthesis and Characterization of Ferrofluid-Chitosan-Au Nanoparticles as Brachytherapy Agent Candidate

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